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Schizophrenia and bipolar disorder are serious mental illnesses that affect more than 2% of adults. While large-scale genetics studies have identified genomic regions associated with disease risk, less is known about the molecular mechanisms by which ...
G. Hoffman+29 more
semanticscholar +1 more source
How patients contribute to an online psychoeducation forum for bipolar disorder: a virtual participant observation study [PDF]
Background: In a recent exploratory randomized controlled trial, an online psychoeducation intervention for bipolar disorder has been found to be feasible and acceptable to patients and may positively impact on their self-management behaviors and ...
Poole, Ria+2 more
core +3 more sources
Assessing neural tuning for object perception in schizophrenia and bipolar disorder with multivariate pattern analysis of fMRI data. [PDF]
IntroductionDeficits in visual perception are well-established in schizophrenia and are linked to abnormal activity in the lateral occipital complex (LOC). Related deficits may exist in bipolar disorder. LOC contains neurons tuned to object features.
Altshuler, Lori L+8 more
core +3 more sources
Cognitive function in bipolar disorder
Introduction In bipolar disorder, cognitive deficits persist across mood episodes and euthymia. Despite recent advances, cognitive impairment in bipolar disorder remains poorly understood.
T. Sparding
doaj +1 more source
Despite decades of research, the pathophysiology of bipolar disorder (BD) is still not well understood. Structural brain differences have been associated with BD, but results from neuroimaging studies have been inconsistent. To address this, we performed
D. Hibar+122 more
semanticscholar +1 more source
Differential efficacy of lithium and carbamazepine in the prophylaxis of bipolar disorder: Results of the MAP study [PDF]
In a randomized clinical trial with an observation period of 2.5 years, the differential efficacy of lithium versus carbamazepine was compared in 171 bipolar patients (DSM-IV).
Greil, Waldemar, Kleindienst, Nikolaus
core +1 more source
Pediatric bipolar disorder (PBD) is a serious mental disorder that affects the development and emotional growth of affected patients. The brain derived neurotrophic factor (BDNF) is recognized as one of the possible markers of the framework and its ...
Tatiana Lauxen Peruzzolo+11 more
doaj +1 more source
To systematically review the existing trials on optimal serum levels for lithium for maintenance treatment of bipolar disorder and to develop clinical recommendations.
W. Nolen+10 more
semanticscholar +1 more source
Bipolar disorder's unique combination of three characteristics - clear genetic diathesis, distinctive clinical features, early availability of an effective treatment (lithium) - explains its special place in the history of psychiatry and its contribution to the current explosive growth of neuroscience.
F K, Goodwin, S N, Ghaemi
openaire +3 more sources
Examining cognition across the bipolar / schizophrenia diagnostic spectrum [PDF]
BACKGROUND: Cognitive impairments are well-established features of schizophrenia, but there is ongoing debate about the nature and degree of cognitive impairment in patients with schizoaffective disorder and bipolar disorder.
Hamshere, Marian L.+7 more
core +1 more source