Results 51 to 60 of about 358,735 (292)

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

El tratamiento a largo plazo del trastorno bipolar

Psicodebate, 2015
Las indicaciones medicamentosas para el tratamiento del trastorno bipolar (TB) requieren de una ponderación de la necesidad de tratamiento del episodio en curso y su evolución a largo plazo. Los objetivos principales radicarán en estabilizar el ánimo,
Leonardo Tondo
doaj   +1 more source

Genome-wide association study identifies 30 loci associated with bipolar disorder. [PDF]

, 2019
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P < 1 × 10-4 in an additional
Abbott, Liam, Agerbo, Esben, Akil, Huda, Albani, Diego, Alliey-Rodriguez, Ney, Als, Thomas D, Anjorin, Adebayo, Antilla, Verneri, Awasthi, Swapnil, Badner, Judith A, Barchas, Jack D, Bass, Nicholas, Bauer, Michael, Belliveau, Richard, Bergen, Sarah E, Boks, Marco P, Boocock, James, Breen, Gerome, Budde, Monika, Bunney, William, Burmeister, Margit, Bybjerg-Grauholm, Jonas, Byerley, William, Byrne, Enda M, Bækvad-Hansen, Marie, Bøen, Erlend, Casas, Miquel, Cerrato, Felecia, Cervantes, Pablo, Chambert, Kimberly, Charney, Alexander W, Chen, Danfeng, Churchhouse, Claire, Clarke, Toni-Kim, Coleman, Jonathan RI, Coryell, William, Craig, David W, Cruceanu, Cristiana, Curtis, David, Czerski, Piotr M, Dale, Anders M, de Jong, Simone, de Leeuw, Christiaan A, Degenhardt, Franziska, Del-Favero, Jurgen, DePaulo, J Raymond, Djurovic, Srdjan, Dobbyn, Amanda L, Dumont, Ashley, Elvsåshagen, Torbjørn, Escott-Price, Valentina, Fan, Chun Chieh, Fischer, Sascha B, Flickinger, Matthew, Foroud, Tatiana M, Forstner, Andreas J, Forty, Liz, Frank, Josef, Fraser, Christine, Freimer, Nelson B, Frisén, Louise, Gade, Katrin, Gage, Diane, Garnham, Julie, Gaspar, Héléna A, Giambartolomei, Claudia, Goldstein, Jaqueline, Gordon, Scott D, Gordon-Smith, Katherine, Green, Elaine K, Green, Melissa J, Greenwood, Tiffany A, Grove, Jakob, Guan, Weihua, Guzman-Parra, José, Hamshere, Marian L, Hautzinger, Martin, Heilbronner, Urs, Herms, Stefan, Hipolito, Maria, Hoffmann, Per, Holland, Dominic, Holmans, Peter A, Huckins, Laura, Jamain, Stéphane, Johnson, Jessica S, Juréus, Anders, Mattheisen, Manuel, McQuillin, Andrew, Pavlides, Jennifer M Whitehead, Pedersen, Carsten Bøcker, Pedersen, Marianne Giørtz, Pers, Tune H, Richards, Alexander L, Ripke, Stephan, Stahl, Eli A, Steinberg, Stacy, Trubetskoy, Vassily, Trzaskowski, Maciej, Wang, Yunpeng   +99 more
core  

Longitudinal Study of Diagnoses in Children of Women With Unipolar and Bipolar Affective Disorder

, 1990
School-age children of unipolar depressed, bipolar, chronically medically ill, or normal women were diagnosed every 6 months for up to 3 years. Offspring of unipolar women had the highest rates of disorder at all evaluations, but children of bipolar and ...
Adrian, Cheri, Burge, Dorli, Hamilton, Elizabeth Burney, Hammen, Constance   +3 more
core   +1 more source

A nationwide study on concordance with multimodal treatment guidelines in bipolar disorder [PDF]

, 2018
Background: Most previous studies on concordance with treatment guidelines for bipolar disorder focused on pharmacotherapy. Few studies have included other treatment modalities.
Hoogendoorn, Adriaan W., Kupka, Ralph W., Nolen, Willem A., Regeer, Eline J., Renes, Joannes W.   +4 more
core   +2 more sources

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source

fNIRS-Based characterization of adolescent depression using dynamic functional connectivity biomarkers in a verbal fluency task

BMC Psychiatry
Background The human brain is a dynamic neural system with time-varying functional connectivity (FC) strengths between brain regions. Evidence indicates that adolescents with major depressive disorder (MDD) exhibit decreased average FC strength in ...
Tongxin Li, Yeqing Dong, Qingyan Jiao, Lijun Chu, Jianli Qiu, Yanlei Fu, Yongyan Gao, Zhonghui Ma, Xia Sun, Yong Zhang   +9 more
doaj   +1 more source

Normal Cerebral Oxygen Consumption Despite Elevated Cerebral Blood Flow in Adolescents With Bipolar Disorder: Putative Neuroimaging Evidence of Anomalous Energy Metabolism

Frontiers in Psychiatry, 2019
Background: Regional cerebral blood flow (CBF) is reportedly altered in both adolescents and adults with bipolar disorder (BD). Whether these CBF differences are part of an overall imbalance in cerebral energy homeostasis remains unknown.
Sudhir Karthikeyan, Lisa Fiksenbaum, Anahit Grigorian, Hanzhang Lu, Bradley J. MacIntosh, Bradley J. MacIntosh, Bradley J. MacIntosh, Benjamin I. Goldstein, Benjamin I. Goldstein, Benjamin I. Goldstein, Benjamin I. Goldstein   +10 more
doaj   +1 more source

The feasibility of mindfulness-based cognitive therapy for people with bipolar disorder: a qualitative study

International Journal of Bipolar Disorders, 2020
Background Mindfulness- Based Cognitive Therapy (MBCT) could be a promising psychosocial intervention for people with bipolar disorder (BD). However, little is known about the feasibility of MBCT for people with BD.
Imke Hanssen, Nicole van der Horst, Marieke Boele, Marc Lochmann van Bennekom, Eline Regeer, Anne Speckens   +5 more
doaj   +1 more source

Psychiatric hospital utilisation following lithium discontinuation in patients with bipolar I or II disorder: A mirror-image study based on the lisie retrospective cohort

European Psychiatry, 2021
Introduction Evidence for lithium as a maintenance treatment for bipolar disorder type II remains limited since most treatment-prevention studies focus on bipolar disorder type I or do not distinguish between types of bipolar disorder.
L. Öhlund, M. Ott, M. Bergqvist, S. Oja, R. Lundqvist, M. Sandlund, E. Salander Renberg, U. Werneke   +7 more
doaj   +1 more source