Results 181 to 190 of about 1,742,691 (356)

In rats, neurodevelopmental disorders induced by maternal hypoxia are associated with attenuated excitatory neurotransmission in the cingulate cortex

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Maternal hypoxia is a recognised risk factor for neurodevelopmental disorders in offspring. Although rodent models of hypoxia have been reported, the detailed pathogenesis of maternal hypoxia‐induced neurodevelopmental disorders remains unclear.
Kentaro Tokudome   +6 more
wiley   +1 more source

Targeting the noncatalytic activity of GSK3β modulates neuronal excitability in medium spiny neurons via Nav1.6 interactions

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Kinases phosphorylate ion channels, but their noncatalytic roles via protein–protein interactions (PPI) are less understood. Here, we identified the peptidomimetic ZL141 to characterize the PPI between GSK3β and Nav1.6, revealing a noncatalytic role for GSK3β in regulating Nav1.6 currents and neuronal excitability ...
Aditya K. Singh   +19 more
wiley   +1 more source

Integer Echo State Networks: Hyperdimensional Reservoir Computing

open access: yes, 2018
We propose an approximation of Echo State Networks (ESN) that can be efficiently implemented on digital hardware based on the mathematics of hyperdimensional computing.
Frady, Edward Paxon   +2 more
core  

Next‐Generation Strategies for Neural Repair and Regeneration: Neural Organoid Transplantation in the CNS

open access: yesCell Proliferation, EarlyView.
Neurological disorders are hard to treat. Stem cell‐derived neural organoids enable research, and their transplantation aids CNS therapy, with this article reviewing relevant advances, challenges and prospects. ABSTRACT Neurological disorders are often devastating and notoriously difficult to repair, creating an urgent need for novel research models ...
Yutong Wang   +8 more
wiley   +1 more source

(Metal) Bipolar Plate Testing

open access: yes, 2017
Rodney Borup   +8 more
openaire   +2 more sources

Disproportional ventilatory response to incremental exercise in individuals with cerebral palsy

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
Individuals with cerebral palsy demonstrate a disproportionate ventilatory response during incremental exercise. Compared with typically developing peers, respiratory frequency increases earlier and at comparable exercise intensities, contributing to higher perceived exertion and reduced ventilatory efficiency. At task failure, respiratory frequency is
Linnéa Corell   +14 more
wiley   +1 more source

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