Results 101 to 110 of about 1,896,118 (310)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Low birth weight, later renal function, and the roles of adulthood blood pressure, diabetes, and obesity in a British birth cohort. [PDF]

, 2013
Low birth weight has been shown to be associated with later renal function, but it is unclear to what extent this is explained by other established kidney disease risk factors.
Silverwood, R.J., Hardy, R, Sattar, N, Sattar, N., Silverwood, Richard J, Pierce, M, Ferro, Charles, Kuh, D., Nitsch, D, Kuh, Diana, Savage, C., Whincup, Peter, Ferro, C., Hardy, R., Savage, Caroline, Pierce, M., Silverwood, Richard J., Hardy, Rebecca, Sattar, Naveed, Whincup, P., Whincup, P, Kuh, D, Silverwood, RJ, Ferro, C, Nitsch, Dorothea, Nitsch, D., Savage, C, Pierce, Mary   +27 more
core   +1 more source

Grandmother, Birth Assistant, Godmother. Grandparents and Newborns in a Spanish Mountain Village (Pedro Bernardo, Ávila, 1850-1861)

Memoria y Civilización
Where a grandmother was alive, she took a very active part in the care of her grandchildren, from the very beginning of their existence. There is considerable evidence for this thesis from Castilian rural communities, rooted in longstanding modes of ...
Wolfram Aichinger, Walburga Plunger
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Mother's education and birth weight [PDF]

Low birth weight has considerable short and long-term consequences and leads to high costs to the individual and society even in a developed economy.
Vincent O'Sullivan, Arnaud Chevalier
core  

Métodos de preparação para o parto: um estudo sobre materiais impressos publicados no Brasil em meados do século XX

História, Ciências, Saúde: Manguinhos
Resumo Discute-se a difusão das práticas de parto natural por meio da análise dos livros Parto natural: guia para os futuros pais, escrito pelo obstetra americano Frederick Goodrich Jr.
Lilian Fernandes Arial Ayres, Luiz Antônio Teixeira, Bruno David Henriques, Anna Karolina Gomes Dias, Wellington Mendonça de Amorim   +4 more
doaj   +1 more source

Uptake of Colostral Immunoglobulins by the Compromised Newborn Farm Animal

Acta Veterinaria Scandinavica, 2003
Neonatal mortality is very high in farm animals (~10%) and disease resistance is greatly influenced by an adequate passive immunisation just after birth. In piglets, foals, calves and lambs, the intestinal absorption of immunoglobulins from their mother'
Sangild PT
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Birth weight and cognitive function in the British 1946 birth cohort: longitudinal population based study

, 2001
Objective To examine the association between birth weight and cognitive function in the normal population.Design A longitudinal, population based, birth cohort study.Participants 3900 males and females born in 1946.Main outcome measures Cognitive ...
Richards, M, Hardy, R, Wadsworth, MEJ, Kuh, D   +3 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source