Results 111 to 120 of about 1,896,118 (310)
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight [PDF]
, 2010 To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591).Steegers, Eric AP, Heinrich, J (Joachim), Berry, Diane J, Freathy, R.M., Lyon, H.N. (Helen), Hypp??nen, Elina, Rivadeneira Ramirez, F. (Fernando), Shields, B.M., McCarthy, Mark I, Kerkhof, M., Beate Glaser, Anneli Pouta, Surakka, I., O'Reilly, Paul F, Palmer, L.J., Dedoussis, G.V. (George), Mook-Kanamori, D.O. (Dennis), Taanila, A. (Anja), Dedoussis, George V, Elliott, Paul, Leslie A Lange, Knight, B.A., Zhao, J, Coin, L.J.M., Joel N Hirschhorn, Vincent W V Jaddoe, Shields, Beverley M., Coin, Lachlan ..J. M., Borja, J., Mirna Kirin, Bridget A Knight, Peltonen, L, Uitterlinden, Andre G., Holly, J.M.P., Holly, J.M.P. (Jeff), Postma, Dirkje S., Marsh, Julie A., Heinrich, J. (Joachim), Evans, D., Groves, Christopher J, Tiesler, C. (Carla), Dedoussis, G., the Early Growth Genetics (EGG) Consortium, Craig E Pennell, Widen, E., Hakonarson, Hakon, Borja, JB, Koppelman, Gerard H, Froguel, P. (Philippe), Heinrich, Joachim, Jarvelin, M., Davey Smith, George, Willemsen, G.A.H.M. (Gonneke), Holly, Jeff M P, Palmer, Lyle J., Grant, SFA, Frayling, Timothy M., Uitterlinden, AG, Susan M Ring, Evans, DM, Timpson, Nicholas J, Linda S Adair, Hofman, A., David P Strachan, Sovio, U, Eric A P Steegers, Marika Kaakinen, Holly, Jeff M. P., Jaddoe, Vincent W. V., Beverley M Shields, Dedoussis, GV, Hartikainen, Anna-Liisa, Jarvelin, Marjo-Riitta, Surakka, Ida, Davey Smith, G., Cecilia M Lindgren, Zhang, H, Nigel W Rayner, Cornelia M van Duijn, Kirin, Mirna, de Geus, Eco J C, Pennell, C.E., Smith, GD, Rivadeneira, F, van Duijn, CM, Lyon, H., Kanoni, S, Warrington, Nicole M., Strachan, David P., Steegers, Eric A. P., Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Jaddoe, V., Maegi, Reedik, Ramasamy, A, Hyppönen, E., Hyppoenen, E, Borja, J.B. (Judith), van Duijn, C., Kanoni, S. (Stavroula), ?, ?, Diana L Cousminer, Dedoussis, George V., Duijn, Cornelia, Borja, Judith B, Matthew W Gillman, Uitterlinden, Andre G, et al., Hakonarson, H., de Geus, EJ, Hyppoenen, Elina, McCarthy, MI, Chen, C.-M., Steegers, Eric, Hyppönen, E. (Elina), Zhao, Jianhua, Hassanali, N. (Neelam), Tiesler, C., Power, Chris, Ring, Susan M, St. Pourcain, M U B, Borja, J.B., Glaser, B, Warrington, Nicole M, Prokopenko, Inga, Pennell, C.E. (Craig), The Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC), Groves, Christopher J., de Geus, E., Freathy, Rachel M., Lyon, HN, Adair, L.S., Fernando Rivadeneira, George Davey Smith, Freathy, R M, Jaddoe, VW, Kanoni, S., Hyppönen, Elina, Haitao Zhang, Jaddoe, VWV, Lyon, Helen N, Nicholas J Timpson, Wijga, AH, Pennell, Craig E, Coin, L., Cousminer, D.L., Gillman, M., Hartikainen, A.-L., Bennett, A.J. (Amanda), Jeff M P Holly, Dennis O Mook-Kanamori, Stavroula Kanoni, Tiesler, C, Paul F O'Reilly, Kerkhof, M. (Marjan), Gillman, MW, Gillman, M.W. (Matthew W.), Ida Surakka, Chen, C.M., van Duijn, C.M., Elina Hyppönen, Laitinen, J, Knight, Bridget A, Duijn, C.M. van, Coin, LJ, Wijga, A., Groves, C.J., Ring, S.M., Uitterlinden, A.G. (André), McArdle, Wendy L., Freathy, Rachel M, Wilson, James F, Laitnen, J, Palmer, Lyle J, Marsh, JA, Mägi, R, Palmer, L., Shields, Beverley M, Jaddoe, Vincent WV, Power, C, Paul Elliott, Marsh, J., Johan G Eriksson, Rayner, N.W., Deloukas, P., Hottenga, JJ (Jouke Jan), Hottenga, J.J., Aulchenko, Y.S., Frayling, T.M. (Timothy), Kerkhof, M, Lange, Leslie A., Kerkhof, Marjan, Palmer, LJ, Andre G Uitterlinden, Anja Taanila, Rachel M Freathy, Wellcome Trust Case Control Consortium, Hirschhorn, J.N. (Joel), Palmer, C. (Cameron), Frayling, TM, Rayner, Nigel W, Strachan, D., Anna-Liisa Hartikainen, Evans, David, McCarthy, M.I., Palmer, L J, Jarvelin, MR, Coin, Lachlan J. M., Adaikalavan Ramasamy, Eco J C de Geus, Uitterlinden, A., van Duijn, Cornelia M., McArdle, W.L. (Wendy), Chen, C. (Chao), Berry, D., Eriksson, J.G., Jarvelin, M.-R., Berry, D. (Diane), Hakonarson, H, Koppelman, Gerard H., Coin, LJM, Deloukas, Panos, Cousminer, D.L. (Diana), Laitinen, Jaana, Tikka-Kleemola, P. (Päivi), Berry, DJ, Wijga, A.H. (Alet), Hagen, K. (Knut), Evans, David M, Wilson, James F., George V Dedoussis, Carla Tiesler, The Wellcome Trust Case Control Consortium (WTCCC), Timpson, Nicholas J., Wijga, A.H., Smith, A.V. (Davey), Hofman, Albert, Zhao, JH, Rayner, N.W. (Nigel William), Nabila Bouatia-Naji, Bouatia-Naji, N, Hirschhorn, Joel N, Lange, Leslie A, Evans, David M., Geus, E.J.C. de, Coin, Lachlan J M, Cousminer, Diana L, Charoen, P. (Pimphen), Strachan, D.P. (David), Alet H Wijga, Pouta, A. (Anneli), Kanoni, Stavroula, Strachan, DP, Widen, E. (Elisabeth), Koppelman, Gerard H.; id_orcid, Coin, Lachlan JM, Elisabeth Widen, Elliott, P., Chen, Chih-Mei, Jonathan P Bradfield, Steegers-Theunissen, R.P.M. (Régine), Laitinen, J., Gillman, Matthew W., Warrington, NM, M??gi, Reedik, Zhao, J., Ramasamy, A., McCarthy, M.I. (Mark), Jianhua Zhao, Marjo-Riitta Jarvelin, Eriksson, Johan G, Aulchenko, Y.S. (Yurii), Mohlke, Karen L, Evans, D.M., Kirin, M, Panos Deloukas, Mägi, R., Cousminer, Diana L., Hartikainen, A.L., Koppelman, G.H. (Gerard), Knight, B., Warrington, N., Dirkje S Postma, Freathy, R., Mohlke, Karen L., Lindgren, Cecilia M., Hattersley, Andrew T., Deloukas, P, Kaakinen, M, Strachan, David P, Peltonen, L., Glaser, B., Shields, B.M. (Beverley), Knight, BA, Kaakinen, Marika, Hassanali, N., Freathy, RM, Chen, CM, Marsh, Julie A, Mohlke, K.L., Freathy, R.M. (Rachel), Bennett, A.J., Bouatia-Naji, Nabila, Chen, C-M, O'Reily, PF, Hofman, Bert, Prokopenko, I. (Inga), Rayner, Nigel W., de Geus, Eco JC, Taanila, Anja, Bennett, Amanda J, Hartikainen, A., Eriksson, Johan G., Heinrich, J., Leena Peltonen, Dorret I Boomsma, Chen, C., Ramasamy, Adaikalavan, Andrew T Hattersley, Rayner, N., Adair, L., Boomsma, D.I. (Dorret), McArdle, W L, Lange, LA, Hartikainen, AL, Hottenga, J.J. (Jouke Jan), Bradfield, J.P. (Jonathan), Taanila, A, Berry, D.J., Charoen, Pimphen, Uitterlinden, André, Steegers, EA, Mohlke, K.L. (Karen), Pouta, Anneli, Lindgren, Cecilia M, Inga Prokopenko, Mägi, R. (Reedik), Chih-Mei Chen, Maegi, R, Sovio, U. (Ulla), Eriksson, JG, Gillman, M.W., Smith, G.D., Surakka, I. (Ida), Hyppönen, E, Helen N Lyon, Timothy M Frayling, Steegers, Eric A P, Grant, S.F.A., Frayling, T., Diane J Berry, Eriksson, J., Lange, L., Power, C., Grant, Struan F A, Rivadeneira, Fernando, Elliott, P. (Paul), Jan Hottenga, J., Zhang, H. (Haitao), Hattersley, A.T., Kirin, M. (Mirna), Grant, S.F.A. (Struan), Willemsen, Gonneke, Zhang, Haitao, Wilson, J.F., Jarvelin, M-R, Karen L Mohlke, Knight, Bridget A., Nicole M Warrington, Mook-Kanamori, DO, Jarvelin, M.-R. (Marjo-Riitta), The Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Coin, L. (Lachlan), Marsh, J.A., Mook-Kanamori, Dennis O., Peltonen, Leena, Adair, LS, Warrington, N.M., Pouta, A., de Geus, E.J.C.; id_orcid, Widen, Elisabeth, Lyle J Palmer, Glaser, Beate, Steegers, E.A.P., Pennell, Craig E., Lindgren, C.M. (Cecilia), Heinrich, J, Gonneke Willemsen, Christopher J Groves, Mook-Kanamori, D., Warrington, N.M. (Nicole), Hassanali, Neelam, Ramasamy, A. (Adaikalavan), Julie A Marsh, Davey Smith, G, Adair, L.S. (Linda), James F Wilson, Lyon, Helen N., Hakonarson, H. (Hakon), Wilson, James F; id_orcid, Mook-Kanamor, Dennis O., Kerhof, M, O'Reilly, P.F., Hassanali, N, Cousminer, DL, Dedoussis, G.V., Jaddoe, Vincent W V, Grant, Struan F. A., McCarthy, Mark I., Neelam Hassanali, Frayling, Timothy M, Charoen, P, Willemsen, G, Borja, Judith B., Boomsma, D.I.; id_orcid, Bradfield, J.P., Ring, S., Struan F A Grant, Timpson, NJ, O'Reilly, Paul F., Boomsma, Dorret I, Holly, J., Hottenga, JJ, Grant, S., Cousminer, D., Pennell, CE, Aulchenko, Yurii S., Boomsma, D., Strachan, D.P., Knight, B.A. (Bridget), de Geus, E.J.C., Bradfield, JP, Willemsen, G.; id_orcid, Prokopenko, I, Uitterlinden, André; id_orcid, Postma, Dirkje S, Surakka, I, Early Growth Genetics (EGG) Consortium, Zhang, H., Aulchenko, Y., Yurii S Aulchenko, Ring, SM, Rivadeneira, F., Hottenga, J., Bradfield, Jonathan P, Holly, JM, Pouta, A, Genetic Investigation of ANthropometric Traits (GIANT) Consortiu, Peltonen, L. (Leena Johanna), McCarthy, M., Hattersley, Andrew T, Gillman, Matthew W, Hattersley, A.T. (Andrew), Smith, George Davey, Postma, D.S., Holly, JMP, Boomsma, Dorret I., Hirschhorn, J.N., McArdle, W.L., Lange, L.A. (Leslie), Reedik Mägi, Prokopenko, I., Bouatia-Naji, N. (Nabila), Jaana Laitinen, Charoen, P., Hofman, A. (Albert), Hattersley, AT, Adair, Linda S., Mägi, Reedik, Sovio, U., Zhao, J.H. (Jing Hua), Groves, C., Mook-Kanamori, D.O., Kaakinen, M., Albert Hofman, Elliott, P, Amanda J Bennett, Koppelman, G., Mohlke, K., Mook-Kanamori, Dennis O, Evans, D.M. (David), Hakon Hakonarson, Jaddoe, V.W.V. (Vincent), Geus, E.J.C. (Eco) de, Koppelman, GH, Timpson, N., Groves, CJ, Boomsma, DI, Bennett, Amanda J., Lyon, H.N., Grant, SF, Hattersley, A., Mohlke, KL, McArdle, Wendy L, Pennell, C., Steegers, E., Grant, Struan FA, David M Evans, Kirin, M., Jaddoe, Vincent, Zhang, HT, Aulchenko, YS, Uitterlinden, A.G., Hottenga, Jouke Jan, Philippe Froguel, Koppelman, G.H., Hirschhorn, J., Jaddoe, V.W.V., Rayner, NW, McArdle, WL, Power, C. (Christopher), Steegers, EAP, Holly, Jeff MP, McArdle, W., Hartikainen, A-L, Tiesler, Carla, Hirschhorn, Joel N., Willemsen, G., O'Reilly, P.F. (Paul), Lindgren, C.M., Bennett, AJ, Lindgren, CM, Groves, C.J. (Christopher), Lange, L.A., Boomsma, D.I., Ulla Sovio, De Geus, EJC, Bennett, A., Hofman, A, Bradfield, Jonathan P., Wilson, JF, Wijga, Alet H., Postma, D., Sovio, Ulla, Shields, B., Kerkhof, Marjon, Aulchenko, Yurii S, Laitinen, J. (Jaana), Frayling, T.M., Froguel, Philippe, Bouatia-Naji, N., Ring, S.M. (Susan), de Geus, Eco J. C., Ring, Susan M., Lindgren, C., Marsh, J.A. (Julie), Widen, E, Bradfield, J., Wilson, J., Mook, Dennis, O'Reilly, PF, Joachim Heinrich, Postma, DS, Chris Power, Lachlan J M Coin, Taanila, A., Jouke Jan Hottenga, Pimphen Charoen, Adair, Linda S, Postma, D.S. (Dirkje), Shields, BM, Timpson, N.J. (Nicholas), Hirschhorn, JN, Wilson, J.F. (James), Glaser, B. (Beate), van Duijn, Cornelia M, Marjan Kerkhof, Wendy L McArdle, Kaakinen, M. (Marika), Deloukas, P. (Panagiotis), Wijga, Alet H, Froguel, P., Timpson, N.J., Judith B Borja, Gerard H Koppelman, Berry, Diane J., O'Reilly, P., Meta-Analyses of Glucose and Insulin-related traits Consortium, Froguel, P +577 morecore +1 more sourceDeciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall +14 morewiley +1 more sourceWomen in the driving seat: birth centre insights
, 2007 Birth centres seek to promote
physiological childbirth by
recognising, respecting and
safeguarding normal birth processes.This
philosophy enableswomen and their
families to experience a positive start to
parenthood (Kirkham2003a).Midwives are
also Deery, Ruth, Phillips, Mari, Jones, Patcore Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig +10 morewiley +1 more sourceOlder and Wiser? Birth Order and IQ of Young Men [PDF]
While recent research finds strong evidence that birth order affects children's outcomes such as education and earnings, the evidence on the effects of birth order on IQ is decidedly mixed. This paper uses a large dataset on the population of Norway that Sandra E. Black, Paul J. Devereux, Kjell G. Salvanes +2 morecore Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...Gabriela Marinescu, Yi Fengwiley +1 more sourceHigh Birth Weight and Cognitive Outcomes [PDF]
While the effects of low birth weight have long been explored, those of high birth weight have been essentially ignored. Economists have analyzed the negative effects that low birth weight might have on subsequent school outcomes, while taking into ...Resul Cesur, Inas Rashadcore Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo +7 morewiley +1 more source
