Results 81 to 90 of about 33,358 (259)

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

open access: yesAdvanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan   +11 more
wiley   +1 more source

Micro‐Galvanic Coupling Programs the Therapeutic Zinc Ion Window to Reconfigure Immune Cascades for Pro‐Regenerative Bone Healing

open access: yesAdvanced Science, EarlyView.
This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun   +14 more
wiley   +1 more source

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

open access: yesAdvanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu   +9 more
wiley   +1 more source

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

open access: yesAdvanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta   +10 more
wiley   +1 more source

Pelayanan pembuatan akta kelahiran menuju transformasi digital di kabupaten Bogor

open access: yesJPPI (Jurnal Penelitian Pendidikan Indonesia)
Because it is impossible to reject the use of technology in public service procedures, the Bogor Regency Population and Civil Registration Service has implemented digital transformation in its operations, including the issuance of birth certificates ...
R.Oetje Subagdja
doaj   +1 more source

Molecules after 20 Years—Looking Back and Looking Forward

open access: yesMolecules, 2015
Twenty years—a long time—so what happens after 20 years? Well if you live in New Zealand, according to [1], if you are adopted you can apply to Births, Deaths and Marriages for a copy of your birth certificate to find the names of your birth parents, you
Derek J. McPhee
doaj   +1 more source

Toronto’s Cartographic Birth Certificate [PDF]

open access: yesOntario History, 2018
This article posits that the earliest map to have ever used the name Toronto as a place is uncovered. Previously unnoticed, the name “Tarontos Lac,” for today’s Lake Simcoe, is on a 1678 map by Jean-Baptiste-Louis Franquelin. His map, “Carte pour servir a l’eclaircissement du Papier Terrier de la Nouvelle France,” is now recognized as ...
openaire   +2 more sources

Smart Exploration of Perovskite Photovoltaics: From AI Driven Discovery to Autonomous Laboratories

open access: yesAdvanced Energy Materials, EarlyView.
In this review, we summarize the fundamentals of AI in automated materials science, and review AI applications in perovskite solar cells. Then, we sum up recent progress in AI‐guided manufacturing optimization, and highlight AI‐driven high‐throughput and autonomous laboratories.
Wenning Chen   +4 more
wiley   +1 more source

Variation in Excessive Fetal Growth across Levels of Prenatal Care among Women with Gestational Diabetes

open access: yesJournal of Primary Care & Community Health, 2011
Objective: Examine the association between prenatal care and excessive fetal growth outcomes among mothers with gestational diabetes mellitus (GDM). Methods: We conducted a retrospective analysis of 2004-2007 singleton live births to South Carolina women,
Nathan L. Hale PhD   +5 more
doaj   +1 more source

Avoiding loss of native individuals in birth certificate data. [PDF]

open access: yesJ Perinatol, 2023
Holloway K   +6 more
europepmc   +1 more source

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