Results 111 to 120 of about 2,893,142 (314)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

What have birth cohort studies asked about genetic, pre- and perinatal exposures and child and adolescent onset mental health outcomes? A systematic review [PDF]

, 2009
Increased understanding of early neurobehavioural development is needed to prevent, identify, and treat childhood psychopathology most effectively at the earliest possible stage.
Thompson, L., Pritchett, P, Gillberg, C., Gillberg, Christopher, Toms-Whittle, L, Puckering, C., Kemp, Jeremy, Gillberg, C, Wilson, P, Toms-Whittle, Louise, Pritchett, R., Pritchett, Rachel, Wilson, P., Pritchett, P., Wilson, Philip, Law, J., Minnis, Helen, Minnis, H, Minnis, H., Toms-Whittle, L., Thompson, Lucy, Puckering, C, Kemp, J., Law, James, Puckering, Christine   +24 more
core   +1 more source

Ethical Foreground and Background in Adult Educator Work

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Adult educators work in a complex ethical environment. The very act of contributing to the learning of another is fraught with moral overtones. In this paper we consider the ethical dimensions of adult educator practice by distinguishing the ethical features of the context or ‘background’ of practice from the ethical capabilities and decision ...
Steven Hodge, Sonal Nakar
wiley   +1 more source

The FinnBrain multimodal neonatal template and atlas collection

Communications Biology
The accurate processing of neonatal and infant brain MRI data is crucial for developmental neuroscience but presents unique challenges that child and adult data do not.
Jetro J. Tuulari, Aylin Rosberg, Elmo P. Pulli, Niloofar Hashempour, Elena Ukharova, Kristian Lidauer, Ashmeet Jolly, Silja Luotonen, Hilyatushalihah K. Audah, Elena Vartiainen, Wajiha Bano, Ilkka Suuronen, Isabella L. C. Mariani Wigley, Vladimir S. Fonov, D. Louis Collins, Harri Merisaari, Linnea Karlsson, Hasse Karlsson, John D. Lewis   +18 more
doaj   +1 more source

Health equity: a lifecourse approach [PDF]

, 2011
This is the author?s version of a work that was accepted for publication in Public Service Review: European Union. A definitive version was subsequently published in Public Service Review: European Union.
Goodman, Anna, Koupil, I, Goodman, A, Koupil, Ilona   +3 more
core  

The combined influence of parental education and preterm birth on school performance.

, 2010
BACKGROUND: Social background and birth characteristics are generally found to be independently associated with school achievements but the underlying mechanisms are not fully understood.
De Stavola, Bianca L, Gisselmann, Marit, De Stavola, B. L., Gisselmann, Marit,, Koupil, Ilona,, Koupil, Ilona, M. Gisselmann, I. Koupil, B. L. De Stavola   +8 more
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Trimester-specific association of maternal prenatal physical activities with risk of preterm birth: a prospective pre-birth cohort study

BMC Pregnancy and Childbirth
This study aimed to examine the trimester-specific association of maternal prenatal physical activities (PA) with risk of preterm birth (PTB). We recruited 2080 women during the first trimester and conducted follow-ups during the second and third ...
Jiajin Hu, Yanan Ma, Wenhan Jia, Ningyu Wan, Xiaochuan Wang, Lu Zheng, Zhe Yang, Dongming Zheng, Jun Wei, Deliang Wen   +9 more
doaj   +1 more source

Ambient temperature exposure during oocyte development and subsequent assisted reproductive outcomes: Potentially susceptible period and embryo-related intermediate pathway

Ecotoxicology and Environmental Safety
Ambient temperature is increasingly recognized as a climate-related environmental stressor with potential implications for human reproductive health; however, potentially susceptible exposure periods and intermediate pathways remain unclear.
Mengwen Yu, Hui Zhu, Jie Cai, Tao Chen, Chunhao Rong, Yiying Wu, Doudou Guo, Chongjing Chen, Yuxian Zhang, Luhui Pan, Lindan Ji, Jin Xu   +11 more
doaj   +1 more source

Birth weight, hypertension and "white coat" hypertension: size at birth in relation to office and 24-h ambulatory blood pressure.

, 2005
We investigated the association of size at birth with hypertensive status defined by office blood pressure (BP) and 24-h ambulatory BP monitoring in a historical cohort study of 736 men born 1920-1924 and examined at age 70 years.
Leon, DA, Koupil, I, Byberg, L
core   +1 more source