Results 41 to 50 of about 312,879 (216)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Maternal mineral nutrition during early pregnancy and neonatal growth: findings from a China birth cohort study

Frontiers in Nutrition
ObjectivesNeonatal growth holds great significance for lifelong health, but the effects of maternal mineral nutrition during pregnancy on neonatal growth remain unclear.
Doudou Zhao, Doudou Zhao, Yanfang Song, Liang Li, Nan Li, Yu Zhang, Yiting Li, Kangxin Wang, Yang Mi, Lei Shang, Pengfei Qu, Pengfei Qu   +11 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Risk Factors for Stunting among Children Aged 24-59 Months: A Case-Control Study in Rural Stunting Hotspots, Yogyakarta, Indonesia

Social Medicine
Background. Stunting remains a major public health nutrition challenge in developing countries, including Indonesia, and is influenced by multiple factors at different levels. Aims.
Bunga Astria Paramashanti, Esti Nugraheny, Siti Masitoh, Mara Ipa, Slamet Riyanto, Nadhea Alriessyanne Hindarta, Lintang Purwara Dewanti, Tri Siswati   +7 more
doaj   +1 more source

The Effect of Maternal Anemia and Umbilical Cord Cortisol Level on Birth Weight and Length [PDF]

Journal of Kerman University of Medical Sciences, 2014
Background & Aims: Maternal anemia in pregnancy is a considerable risk factor for both mother and fetus. Growth retardation, intra uterine fetal death, maternal cardiovascular symptoms and reduction in blood supply are among outcomes of maternal anemia ...
T Naderi, A Barkhordari
doaj  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Telomere tracking from birth to adulthood and residential traffic exposure

BMC Medicine, 2017
Background Telomere attrition is extremely rapid during the first years of life, while lifestyle during adulthood exerts a minor impact. This suggests that early life is an important period in the determination of telomere length.
Esmée M. Bijnens, Maurice P. Zeegers, Catherine Derom, Dries S. Martens, Marij Gielen, Geja J. Hageman, Michelle Plusquin, Evert Thiery, Robert Vlietinck, Tim S. Nawrot   +9 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Size at birth and blood pressure in young adults: findings from a Brazilian birth cohort study Tamaño al nacer y presión arterial en adultos jóvenes: resultados de una cohorte de nacimientos brasileña Tamanho ao nascer e pressão arterial em adultos jovens: achados de uma coorte de nascimentos brasileira

Revista de Saúde Pública, 2012
OBJETIVO: Describir la prevalencia de presión arterial limítrofe (PAL) e hipertensión (HT) entre adultos jóvenes y evaluar la asociación entre tamaño al nacer y PAL/HT. MÉTODOS: : Los datos fueron colectados en el primer estudio de cohorte de nacimientos
Viviane Cunha Cardoso, Javier Meritano, Antônio Augusto Moura da Silva, Heloísa Bettiol, Marco Antonio Barbieri, Carlos Grandi   +5 more
doaj