Results 51 to 60 of about 1,916,076 (342)

Malthus Was Right After All: Poor Relief and Birth Rates in Southeastern England [PDF]

, 1989
The payment of child allowances to laborers with large families was widespread in early nineteenth-century England. This paper tests Thomas Malthus\u27s hypothesis that child allowances caused the birth rate to increase.
Boyer, George R
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

A Causal Analysis of Life Expectancy at Birth. Evidence from Spain [PDF]

, 2019
Background: From a causal point of view, there exists a set of socioeconomic indicators concerning life expectancy. The objective of this paper is to determine the indicators which exhibit a relation of causality with life expectancy at birth.
Cruz Rambaud, Salvador, Martín Cervantes, Pedro Antonio, Rueda López, Nuria   +2 more
core   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

THE CHARACTERISTIC OF ECOLOGICAL-GEOGRAPHICAL DISTRIBUTION OF SYSTEM BLOOD CIRCULATION'S ILLNESSES OF DAGESTAN

Юг России: экология, развитие, 2014
Death rate from illnesses of cardiovascular system makes more than half of all death, being one of principal causes of a considera-ble gain of death rate in Russia.
E. S. Erzhapova, E. G. Abdurahmanova, T. I. Gayrabekova   +2 more
doaj   +1 more source

Age and Huddling as Determinants of Metabolic Rate in Grasshopper Mice (Onychomys leucogaster) [PDF]

, 1979
The metabolic rates of grasshopper mice (Onychomys leucogaster) were determined every third day from birth to adulthood. Metabolic rates were quantitated by measuring oxygen consumption in an open circuit system.
Baeyens, Dennis A., Bailey, Meredith, Mann, Lana   +2 more
core   +2 more sources

The single-degenerate channel for the progenitor of type Ia supernovae with different metallicities [PDF]

, 2009
The single-degenerate channel for the progenitors of type Ia supernovae (SNe Ia) are currently accepted, in which a carbon-oxygen white dwarf (CO WD) accretes hydrogen-rich material from its companion, increases its mass to the Chandrasekhar mass limit ...
Aldering, Alexander, Arnett, Arnett, Baes, Benetti, Branch, Branch, Branch, Branch, Cappellaro, Cappellaro, Chen, Chen, Chen, Chen, Chugai, Deng, Di Stefano, Eggleton, Eggleton, Eggleton, Eggleton, Ergma, Geier, Girardi, Goldberg, Guo, Hachisu, Hachisu, Hachisu, Hachisu, Hachisu, Hachisu, Hachisu, Hachisu, Hachisu, Hachisu, Hamuy, Hamuy, Hamuy, Han, Han, Han, Han, Han, Han, Han, Hillebrandt, Hjellming, Howell, Hurley, Hurley, Iben, Iglesias, Ihara, Kato, Kippenhahn, Kobayashi, Kotak, Langer, Leibundgut, Lemasle, Leonard, Li, Liebert, Liebert, Livio, Livio, Mannucci, Mannucci, Mattila, Mazeh, Meng, Meng, Miller, Napiwotzki, Nelemans, Nelemans, Nomoto, Nomoto, Nomoto, Ofek, Paczyński, Parthasarathy, Patat, Perlmutter, Phillips, Podsiadlowski, Pols, Pols, Pols, Prieto, Quimby, Riess, Riess, Ruiz-Lapuente, Scannapieco, Schröder, Shanks, Timmes, Timmes, Totani, Travaglio, Tutukov, Uenishi, Umeda, van den Bergh, Voss, Wang, Wang, Wang, Webbink, Webbink, Whelan, Whelan, Wickramasinghe, Willems, Wood-Vasey, Wood-Vasey, X. Chen, X. Meng, Yungelson, Yungelson, Yungelson, Z. Han   +125 more
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Demographic transition in South Korea: implications of falling birth rates [PDF]

Clinical and Experimental Pediatrics
This review examines the critical issues of declining total fertility rates (TFRs) and aging populations in East Asia with special focus on South Korea.
Chae Young Kim, Sung-Hoon Chung
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source