Results 11 to 20 of about 516,619 (288)
In Vivo Secretion of Bispecific Antibodies Recruiting Lymphocytic Effector Cells
Antibodies, 2013 Engineered Fc-lacking bispecific antibodies have shown an exceptionally high potency for recruiting lymphocyte effector cells and enhancing antitumor activity, which is under evaluation in several clinical trials.
Luis Alvarez-Vallina +3 more
doaj +2 more sources
Drug Discovery Today, 2015 Bispecific antibodies (bsAbs) combine specificities of two antibodies and simultaneously address different antigens or epitopes. BsAbs with ‘two-target’ functionality can interfere with multiple surface receptors or ligands associated, for example with ...
Ulrich Brinkmann +3 more
core +7 more sources
Taking up Cancer Immunotherapy Challenges: Bispecific Antibodies, the Path Forward?
Antibodies, 2015 As evidenced by the recent approvals of Removab (EU, Trion Pharma) in 2009 and of Blincyto (US, Amgen) in 2014, the high potential of bispecific antibodies in the field of immuno-oncology is eliciting a renewed interest from pharmaceutical companies ...
Joanie Del Bano +3 more
doaj +2 more sources
Intein mediated high throughput screening for bispecific antibodies [PDF]
mAbs, 2020 Bispecific antibodies comprise extremely diverse architectures enabling complex modes of action, such as effector cell recruitment or conditional target modulation via dual targeting, not conveyed by monospecific antibodies.
Tim Hofmann +8 more
doaj +2 more sources
Site-specific PEGylation of an anti-CEA/CD3 bispecific antibody improves its antitumor efficacy
International Journal of Nanomedicine, 2018 Haitao Pan,1,2 Jiayu Liu,1,2 Wentong Deng,1,2 Jieyu Xing,1,2 Qing Li,1,2 Zhong Wang1,2 1School of Pharmaceutical Sciences, 2Centre for Cellular & Structural Biology, Sun Yat-Sen University, Guangzhou, People’s Republic of China Introduction ...
Pan H +5 more
doaj +1 more source
Bispecific brain-penetrant antibodies for treatment of Alzheimer’s disease
The Journal of Prevention of Alzheimer's DiseaseThe emerging class of bispecific antibodies represents a significant advancement in Alzheimer’s disease (AD) immunotherapy by addressing the limited brain concentrations achieved with conventional monoclonal antibodies.
Dag Sehlin +8 more
doaj +2 more sources
Bispecific antibodies in follicular lymphoma [PDF]
HaematologicaBispecific antibodies, specifically anti-CD20 T-cell engaging constructs, are poised to alter the treatment paradigm of multiple B-cell malignancies, including follicular lymphoma.
Imran A. Nizamuddin, Nancy L. Bartlett
doaj +2 more sources
Modular chemical construction of IgG-like mono- and bispecific synthetic antibodies (SynAbs) [PDF]
, 2022 In recent years there has been rising interest in the field of protein–protein conjugation, especially related to bispecific antibodies (bsAbs) and their therapeutic applications.
Jaine K., Blayney +9 more
core +2 more sources
Bispecific Antibodies Produced via Chemical Site-Specific Conjugation Technology: AJICAP Second Generation [PDF]
, 2023 Bispecific antibodies are biotherapeutics that amalgamate the specificities of two distinct antibodies into one molecule. Bispecific antibodies can be utilized in a broad range of diagnostic and therapeutic applications; however, their engineering ...
Rika, Takasugi +12 more
core +2 more sources
mAbs, 2020 The development of antibody therapeutics relies on animal models that accurately recapitulate disease biology. Syngeneic mouse models are increasingly used with new molecules to capture the biology of complex cancers and disease states, and to provide ...
Feng Wang +17 more
doaj +1 more source