Results 181 to 190 of about 827 (246)

Modular architecture confers robustness to damage and facilitates recovery in spiking neural networks modeling <i>in vitro</i> neurons. [PDF]

Front Neurosci
Sumi T, Houben AM, Yamamoto H, Kato H, Katori Y, Soriano J, Hirano-Iwata A.   +6 more
europepmc   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Physiological and functional characterization for high-throughput optogenetic skeletal muscle exercise assays. [PDF]

Bioeng Transl Med
Heisser RH, Bu A, Schwendeman L, Rossy T, Umashankar P, Butty V, Raman R.   +6 more
europepmc   +1 more source

Pressure‐Driven Phase Transition Unlocking Unique Eu2+ Luminescence in Li2SrSiO4 for Optical Sensing and White‐LEDs

Advanced Science, EarlyView.
This study demonstrates, for the first time, the use of a large‐format high‐pressure press to modify synthesized Li2SrSiO4:Eu2+,Cs+ phosphors after its preparation. The pressure treatment results in the formation of new materials with distinctive optical properties, opening pathways for the development of advanced LED devices and high‐performance ...
Przemysław Woźny, Peng Du, Teng Zheng, Junpeng Xue, Liang Peng, Shuailing Ma, Szymon Sobczak, Victor Lavín, Tian Cui, Marcin Runowski   +9 more
wiley   +1 more source

What is the impact of a shift to remote consultations? A qualitative interview study in primary and secondary healthcare. [PDF]

BMJ Open
Chaloner C, Stevenson FA, Rehill N, Halvorsrud K, Raine R, Barratt H.   +5 more
europepmc   +1 more source

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source

NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity

Advanced Science, EarlyView.
Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li, Xin‐Yuan Zhao, Min Zhang, Zhuang‐Feng Weng, Xiao‐Ran Guo, Ying‐Fang Liu, Qiao‐Ping Wang, Huan‐Huan Liang   +7 more
wiley   +1 more source

Specification of human brain regions with orthogonal gradients of WNT and SHH in organoids reveals patterning variations across cell lines. [PDF]

Cell Stem Cell
Scuderi S, Kang TY, Jourdon A, Nelson A, Yang L, Wu F, Anderson GM, Mariani J, Tomasini L, Sarangi V, Abyzov A, Levchenko A, Vaccarino FM.   +12 more
europepmc   +1 more source

Stress Accumulation Induced by Ion Exchange for Synchronous Modulation of Mode and Wavelength in Microlasers

Advanced Science, EarlyView.
This work demonstrates a paradigm‐shifting strategy to simultaneously achieve broadband wavelength tunability and single‐mode control within a single perovskite microwire structure. Using a facile heating‐assisted solid–solid anion‐exchange strategy, we synthesized phase‐pure CsPbClxBr3‐x microwires that exhibit the widest reported continuous lasing ...
Bingwang Yang, Lingling Sun, Jinhui Wang, Jitao Li, Peng Wan, Daning Shi, Caixia Kan, Mingming Jiang   +7 more
wiley   +1 more source