Results 191 to 200 of about 1,568 (284)

Pupillary response test as a potential early diagnosis biomarker of Alzheimer's disease. [PDF]

Dement Neuropsychol
Shen R, Turana Y, Handajani YS, Lukas, Widjaja NT, Budiyanta NE, Sumarta RAP, Wahyudi CG, Wijaya HT, Barus JFA, Suryakusuma L, Sasmita PK, Sani TP.   +12 more
europepmc   +1 more source

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

Probe-Based Mechanical Data Storage on Polymers Made by Inverse Vulcanization. [PDF]

Adv Sci (Weinh)
Mann AK, Tonkin SJ, Sharma P, Gibson CT, Chalker JM.   +4 more
europepmc   +1 more source

The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos

Advanced Science, EarlyView.
Histone crotonylation undergoes a genome‐wide transition from broad domains to canonical narrow peaks during minor zygotic genome activation (ZGA). This remodeling is required for proper major ZGA and blastocyst formation. Disruption of this transition by transcriptional inhibition, metabolic perturbation, or HDAC1 dysfunction impairs embryonic ...
Shenli Yuan, Yelian Yan, Yalin Liang, Kanghua Zhong, Zhican Fu, Xiaobo Wang, Chao Liu, Tao Huang, Keliang Wu   +8 more
wiley   +1 more source

Universal modulus-free transfer of scalable laser-induced graphene for electronic skins. [PDF]

Nat Commun
Lu Y, Jin Z, Sheng Q, Kong D, Miao C, Wu H, Pang G, Xie H, Xie L, Yang G, Zou J, Yang H, Huang W, Xu K.   +13 more
europepmc   +1 more source

Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell Ferroptosis Through GSK3β Dependent Ubiquitin‐Mediated NRF2 Degradation

Advanced Science, EarlyView.
Lipid metabolic stress triggers ferroptosis in PDLSCs through the GSK3β/NRF2 pathway, thereby aggravating periodontal bone loss. Upregulated GSK3β promotes NRF2 ubiquitination and proteasomal degradation via β‐TrCP, suppressing NRF2 nuclear translocation and antioxidant target expression.
Yuxiao Zhang, Xiangyao Wang, Yaxin Wu, Liping Liu, Gaoshaer Nuerlan, Ahsawle Ozathaley, Xiaorui Zhang, Jinping Wang, Bowen Yang, Jing Mao, Yan Liu, Shiqiang Gong   +11 more
wiley   +1 more source

Inkube: an all-in-one solution for neuron culturing, electrophysiology, and fluidic exchange.

Lab Chip
Maurer B, Fassbind S, Ruff T, Duru J, Spacone G, Rodde T, Vörös J, Ihle SJ.   +7 more
europepmc   +1 more source

Effect of electrochemical topology on detection sensitivity in MEA assay for drug-induced cardiotoxicity screening. [PDF]

Biosens Bioelectron
Kim B, Choi JS, Zhu Y, Kim J, Kim YS, Parra A, Locke PA, Kim JH, Herron T, Kim DH.   +9 more
europepmc   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

Improving access and uptake of lung cancer screening with a focus on health inequity: the views of professionals involved in the UK NHS lung cancer screening programme. [PDF]

BMC Cancer
Kapadi A, Howard G, Merchant Z, Crosbie PAJ, French DP, McWilliams L.   +5 more
europepmc   +1 more source