Results 91 to 100 of about 1,726,359 (308)

Quantum key distribution over 122 km of standard telecom fiber

, 2004
We report the first demonstration of quantum key distribution over a standard telecom fiber exceeding 100 km in length. Through careful optimisation of the interferometer and single photon detector, we achieve a quantum bit error ratio of 8.9% for a ...
A. J. Shields, C. Gobby, Hughes R. J., Z. L. Yuan   +3 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Unveiling spatial domains from spatial multi-omics data using dual-graph regularized ensemble learning

Communications Biology
With the rapid advancement of spatial multi-omics technologies, the simultaneous analysis of molecular profiles and spatial locations has provided unprecedented insights into cellular heterogeneity and tissue microenvironments. However, data sparsity and
Ying Li, Guangchang Cai, Fuqun Chen, Kepei Wen, Le Ou-Yang   +4 more
doaj   +1 more source

Related-Key Differential Attacks on COSB-128

International Journal of Distributed Sensor Networks, 2015
COSB-128 (Moldovyan et al., 2002) is a block cipher with 128-bit and 256-bit secret keys, which use key and data-dependent operational substitutions in fast controllable permutation blocks (CPB) concept.
Song Dat Phuc Tran, Changhoon Lee
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Block encryption of quantum messages [PDF]

, 2018
In modern cryptography, block encryption is a fundamental cryptographic primitive. However, it is impossible for block encryption to achieve the same security as one-time pad.
Liang, Min, Yang, Li
core   +1 more source

Experimental Decoy Quantum Key Distribution Up To 130KM Fiber

, 2007
Decoy State Quantum Key Distribution (QKD), being capable of beating PNS attack and uncon- ditionally secure, have become an attractive one recently.
Bennett C H, Chen Wei, Gottesman D, Guo Guang-Can, Han Zheng-Fu, Stucki D, Wu Qing-Lin, Xu Fang-Xing, Yin Zhen-Qiang, Zhao Y   +9 more
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Achieving high oxygen tolerance in Ti6Al4V: Copper-oxygen co-doping strategy for ultrahigh strength-ductility balance

Materials & Design
Conventional α + β Ti6Al4V alloys lack sufficient strengthening mechanisms, limiting strength. While oxygen (O) offers a cost-effective strengthening route, exceeding ∼ 0.33 wt% causes significant embrittlement.
Hongqiang Duan, Hongmei Zhang, Xingwang Cheng, Xiaonan Mu, Qunbo Fan, Ying Zhang, Ni Xiong, Ke Feng, Yu Wang, Xuexia Li, Taotao Cai, Kefan Zheng   +11 more
doaj   +1 more source