Results 41 to 50 of about 172,827 (313)

Human bite facial wounds in Bouaké (Côte d'Ivoire): development of a therapeutic algorithm in underdeveloped countries

Journal of Oral Medicine and Oral Surgery, 2020
Introduction: The treatment of facial wounds by human bites is difficult, especially in under-developed countries. We aimed to distinguish the epidemiological and clinical aspects to describe the therapeutic methods and evaluate their effectiveness ...
Zegbeh-N'guessan Eric Kouassi, Bérété Pornan Issa Jules, Salami Tahib Arnaud, Assouan Camille, Assi Yapo Romaric Evrard, Crezoit Grébéret Emmanuel   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Treatment of a Deep Bite Malocclusion with Extraction and Bite-Fixer

, 2008
This case report presents the treatment of a deep-bite malocclusion by premolar extraction and Bite-fixer appliance. A 13-year-old female patient concerned about the appearance of her crooked upper teeth.
Müge Aksu, Germec, Derya, Ugur-Taner, Tulin, Tülin Uğur-Taner, AKSU, MÜGE, Derya Germeç   +5 more
core   +1 more source

3D printer-driven design of a non-assembly titanium surgical instrument using compliant lattice flexures

Materials & Design
Metal additive manufacturing is a promising technology for the production of functional medical products, due to its high shape complexity and resolution, and ability to withstand sterilization temperatures.
Kirsten Lussenburg, Remi van Starkenburg, Aimée Sakes, Paul Breedveld   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Morphological Changes in the Mandibles Accompany the Defensive Behavior of Indiana Mite Biting Honey Bees Against Varroa Destructor

Frontiers in Ecology and Evolution, 2021
The honey bee (Apis mellifera) is the most important managed pollinator to sustainable agriculture and our ecosystem. Yet managed honey bee colonies in the United States experience 30–40% losses annually.
Jada Smith, Xaryn L. Cleare, Krispn Given, Hongmei Li-Byarlay, Hongmei Li-Byarlay   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Leishmania infantum proteophosphoglycans regurgitated by the bite of its natural sand fly vector, Lutzomyia longipalpis, promote parasite establishment in mouse skin and skin-distant tissues

, 2010
We demonstrate that a proteophosphoglycan-rich gel secreted by Leishmania infantum inside the midgut of Lutzomyia longipalpis sand flies (promastigote secretory gel) is regurgitated along with an average dose of 500 L.
Müller, Ingrid, Bates, Paul Andrew, Corware, Karina, Matthew Edward Rogers, Karina Corware, Rogers, Matthew Edward, Paul Andrew Bates, Ingrid Müller   +7 more
core   +1 more source

Steering strategies for wasp inspired self propelled needles

Scientific Reports
Positioning a thin needle into a solid substrate near a target region is difficult because the needle can easily bend and buckle. Nevertheless, in nature, female parasitic wasps can do this by using buckling prevention and steering mechanisms. This study
Jette Bloemberg, David Justin Jager, Paul Breedveld, Aimée Sakes   +3 more
doaj   +1 more source