Results 51 to 60 of about 48,770 (265)

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

Evaluation of the spatial distribution pattern of animal bites in Southern Iran: implications for public health interventions

open access: yesBMC Veterinary Research
Introduction Animal bites are an important and dangerous threat to human health, and in many cases, the venom from the bite or the subsequent infections can threaten human life.
Hossein Ghazanfarpour   +3 more
doaj   +1 more source

Limits of human bite strength

open access: yesThe Journal of Prosthetic Dentistry, 1986
lhe greatest human bite strength in the early literature was reported more than 300 years ago by Borelli of Rome, Italy, in 1681.’ He attached weights to a cord, which passed over the molar teeth of the open mandible, and with closing of the jaw, up to 440 lbs (200 kg) were raised.’ In recent times, the greatest reported bite strength was 348 lbs (158 ...
University of Florida, Colleges of Dentistry and Engineering, Gainesville, Fla.U.S.A. ( host institution )   +5 more
openaire   +3 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Malaria burden and residual transmission: two thirds of mosquito bites may not be preventable with current vector control tools on Bioko Island, Equatorial Guinea

open access: yesInternational Journal of Infectious Diseases
Objectives: This study assesses exposure to malaria vector mosquitos that is nonpreventable through use of nets, the contribution of outdoor and indoor biting towards residual vector exposure, and the risk factors for being bitten and for being infected ...
Michael Ooko   +12 more
doaj   +1 more source

Biting Humans by Dogs (General Description) [PDF]

open access: yesЖурнал Сибирского федерального университета: Серия Биология, 2013
The analysis of appeals for medical help concerned with dog bites made by dwellers of the Omsk City in 2006-2010 has been performed, using the materials of the “Omsk Regional Center for Hygiene and Epidemiology”.
Marat T. Makenov, Olga A. Mihaylova
doaj  

Chiggers

open access: yesEDIS, 1999
This document provides an overview of chiggers, detailing their biology, life cycle, and the effects of their bites. Chiggers, or “red bugs,” are larvae of mites that cause intense itching and welts on human skin.
P.G. Koehler
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

Transmission of Severe Fever with Thrombocytopenia Syndrome (SFTS) to humans: A systematic review of individual participant data and meta-analysis

open access: yesJournal of Infection and Public Health
Severe Fever with Thrombocytopenia Syndrome (SFTS) is a life-threatening emerging infectious disease caused by the SFTS virus. The aim of this systematic review and meta-analysis was to gain new insights into the routes of transmission to humans and ...
Darae Woo   +4 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

open access: yesMolecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho   +2 more
wiley   +1 more source

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