Results 91 to 100 of about 87,999 (333)

Evidence that 5‐HT2A receptor signalling efficacy and not biased agonism differentiates serotonergic psychedelic from non‐psychedelic drugs

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Serotonergic psychedelic drugs are under investigation as therapies for various psychiatric disorders, including major depression. Although serotonergic psychedelic drugs are 5‐HT2A receptor agonists, some such agonists are not psychedelic, potentially due to differences in 5‐HT2A receptor ligand bias or signalling efficacy. Here,
Aurelija Ippolito   +6 more
wiley   +1 more source

Activation of peripheral NOP receptors reduces periorbital mechanical allodynia evoked by CGRP in mice

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Migraine is a neurovascular disorder largely mediated by calcitonin gene‐related peptide (CGRP). This study explores the role of the nociceptin/orphanin FQ (N/OFQ)–N/OFQ receptor (NOP) system in CGRP‐induced periorbital mechanical allodynia (PMA) in mice.
Chiara Sturaro   +14 more
wiley   +1 more source

Policy Diffusion Among Domestic Political Parties in Multiparty Systems: An Analysis of Election Manifestos of Indian Political Parties

open access: yesHatfield Graduate Journal of Public Affairs
Do political parties adopt each others’ ideas? This research argues that parties are more likely to employ party platforms from electorally successful domestic parties in a multiparty system while seeking public office.
Payel Nasrin
doaj   +1 more source

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

open access: yesBritish Journal of Pharmacology, EarlyView.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller   +3 more
wiley   +1 more source

PERANAN SEKTOR PERTANIAN DALAM PEMBANGUNAN WILAYAH DI ERA OTONOMI DAERAH KABUPATEN KARANGANYAR

open access: yesCaraka Tani: Journal of Sustainable Agriculture, 2009
In era regional autonomy which the regional economic development not follow the central development paradigm, but the development base on the initiative and the carrying capacity of region.
Agustono Agustono   +2 more
doaj   +1 more source

New biosensors and transgenic mice for multiplex cGMP imaging

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters   +6 more
wiley   +1 more source

Data on the densification during sintering of binder jet printed samples made from water- and gas-atomized alloy 625 powders

open access: yesData in Brief, 2017
Binder jet printing (BJP) is a metal additive manufacturing method that manufactures parts with complex geometry by depositing powder layer-by-layer, selectively joining particles in each layer with a polymeric binder and finally curing the binder. After
Amir Mostafaei   +4 more
doaj   +1 more source

India’s elections: results from the biggest event in the world [PDF]

open access: yes, 2014
The Bharatiya Janata Party (BJP) won 282 seats in the 543-member Lok Sabha, becoming the first party other than Congress to win a parliamentary majority without coalition partners.
South Asia, LSE
core  

Home - About - Disclaimer - Privacy