Results 121 to 130 of about 21,639 (283)

MCL‐1 inhibition triggers a largely reversible cardiac stress signature in a humanised mouse model

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Myeloid cell leukaemia‐1 (MCL‐1) is an essential anti‐apoptotic protein and a promising therapeutic target in oncology. Early clinical studies of MCL‐1 inhibitors reported unexpected elevations in cardiac troponin, raising concerns about potential cardiotoxicity.
Markus B. Heckmann, Zsanett Papdi, Nils J. Strauch, Daniel Finke, Marc‐Steffen Raab, Antje Blank, Norbert Frey, Lorenz H. Lehmann   +7 more
wiley   +1 more source

Maintaining Federal Autonomy in a BJP-dominant System: The Special Case of Nagaland in India’s Northeast

South Asia Multidisciplinary Academic Journal
This paper seeks to explore the implications the changing party system in India has for the unique federal relationship with the Northeast State of Nagaland.
Smitana Saikia
doaj   +1 more source

CSDS-Lokniti | Analysing the social media presence of the BJP and the Congress

As the 2024 Lok Sabha Elections draw close, all parties are diving headfirst into the digital realm, cementing their presence and that of their party beyond the traditional campaign trail.
Kumar, Sanjay, Majumdar, Subhayan Acharya, Singh, Aditi, Nair, Anagha V.   +3 more
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Selective modulation of NaV channel gating counteracts aberrant hyperexcitability and rescues motor function and survival in a model of spinal muscular atrophy

British Journal of Pharmacology, EarlyView.
Background and Purpose Spinal muscular atrophy (SMA) is a motor neuron disease caused by SMN1 gene loss, leading to reduced survival motor neuron (SMN) protein and progressive motor neuron degeneration. Although SMN‐restoring therapies improve outcomes, residual disease burden and non‐curative efficacy underscore the need for complementary treatments ...
Fernanda C. Cardoso, Jessica A. I. Muller, Yougang Zhang, Jean Giacomotto   +3 more
wiley   +1 more source

The combination of blueberry juice and probiotics reduces apoptosis of alcoholic fatty liver of mice by affecting SIRT1 pathway

Drug Design, Development and Therapy, 2016
Juanjuan Zhu,1,2,* Tingting Ren,3,* Mingyu Zhou,2 Mingliang Cheng2 1First Hospital Affiliated to Suzhou University, Suzhou, 2Department of Infectious Diseases, 3Biochemistry Department, Affiliated Hospital of Guiyang Medical College, Guiyang, People ...
Zhu J, Ren T, Zhou M, Cheng M,
doaj  

Bayesian Joint Probability Approach for Post‐Processing Monthly Precipitation Prediction in Northwest Iran

Water Resources Research
The probabilistic prediction of monthly precipitation events, specifically more‐than‐normal (MN), normal (N), and less‐than‐normal (LN) events, holds significant importance in the field of water resource management.
Z. Javanshiri, M. Pakdaman
doaj   +1 more source

The Rise of Social Media and the Fall of the Muslim Minority in India: The Case of WhatsApp

Journal of Mass Communication
This study aims to establish how WhatsApp usage has shifted people’s perception of the BJP and India’s political strategy since 2014. From interviews with Academicians and students of Delhi, it can be pointed out that through the application of WhatsApp,
Abdul Fahad, Dr. Siti Ezaleila Mustafa, and Dr. Muhammad Luqman
doaj   +1 more source

NMDA receptor subunit‐dependent analysis of radiprodil inhibition in neonatal male rat substantia nigra dopaminergic neurons

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Radiprodil is a GluN2B subunit selective NMDA receptor negative allosteric modulator which is currently under clinical investigation as a possible anti‐epileptic drug for paediatric use. Our goal was to investigate the inhibition of dopaminergic neuron NMDA responses by radiprodil.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source

Signal detection and characterisation of a novel drug–drug interaction between methadone and a synthetic cannabinoid receptor agonist

British Journal of Pharmacology, EarlyView.
Background and Purpose Little is known about how synthetic cannabinoid receptor agonist (SCRA) co‐use with other psychoactive substances may exacerbate risk of death. This study aimed to characterise the polypharmacy of deaths where SCRAs were detected at post‐mortem, investigate the cardiotoxicity of SCRAs and probe their inhibition of human ether‐a ...
Kirsten L. Rock, Louise M. Hesketh, Hongwei Cheng, Shuoqi Chen, Simon Hudson, Graeme Henderson, Jules C. Hancox, Michael J. Shattock, Michael J. Curtis, Caroline S. Copeland   +9 more
wiley   +1 more source

BJP in an unenviable spot in Haryana

The BJP in Haryana faces an uphill task in the forthcoming assembly elections on several counts, not the least significant of which is the discontent among party workers. Granted that it is common with every party to feel the heat near election time with
Batra, Jagdish
core