Results 211 to 220 of about 21,639 (283)

Harnessing clinical hypnosis to improve paediatric pain management. [PDF]

Br J Pain
Liossi C.
europepmc   +1 more source

Receptor kinetics: Binding flux‐based approaches offer complementary insight into how ligand binding evolves with time

British Journal of Pharmacology, Volume 183, Issue 21, Page 6444-6457, November 2026.
Background and Purpose Binding kinetics are essentially based on rate constants. Yet, this view has been challenged by the idea that ‘binding fluxes’ are dynamic and therefore more relevant. Those fluxes refer to the rate at which a target/receptor changes from one state into another through ligand/drug binding or a conformational change.
Georges Vauquelin, Terry Kenakin, Dominique Maes   +2 more
wiley   +1 more source

The harming power of shame. [PDF]

Br J Psychiatry
Lawlor B, Baez S, Santamaría-García H, Ibanez A.   +3 more
europepmc   +1 more source

Chemoproteomic discovery of a brain‐penetrant, covalent NLRP3 inhibitor that binds a novel allosteric pocket

British Journal of Pharmacology, Volume 183, Issue 22, Page 6718-6734, November 2026.
NLRP3 is a promising inflammatory target, but existing inhibitors lack diversity and brain penetrance, and none are approved. Using chemoproteomics, we discovered a novel series that binds to Cys463 in a previously uncharacterized pocket. Compounds showed nanomolar potency, brain exposure, and in vivo suppression of IL‐1β, supporting neuroinflammatory ...
Donald C. Rogness, Evelyn P. Sievert, Vincent F. Vartabedian, Steffen M. Bernard, Erick Aitchison, William Tao, Mikaela Lindvall, Jing Qian, Christie L. Eissler, Brian E. Nordin, Benjamin D. Horning, Cian Kingston, Kelsey N. Lamb, Joshua C. Bell, Bingwen Lu, Jonathan Pollock, Jun Shi, Roli Khattri, David S. Weinstein, Matthew P. Patricelli, Brian N. Cook, Gabriel M. Simon   +21 more
wiley   +1 more source

Trajectories of depression across key events in later life: findings from the English Longitudinal Study of Ageing. [PDF]

Br J Psychiatry
Beach B, Shim EJ, Iob E, Zaninotto P.
europepmc   +1 more source

Factors associated with self-harm in patients with substance use disorders who died by suicide: national hybrid questionnaire registry study. [PDF]

Br J Psychiatry
Myhre MØ, Walby FA, Klungsøyr O, Bramness JG, Mehlum L.   +4 more
europepmc   +1 more source

Influence of Intravenous Norepinephrine Administration on Melatonin Plasma Concentration in Awake and Anaesthetised Healthy Adult Volunteers

Journal of Pineal Research, Volume 78, Issue 6, November 2026.
ABSTRACT Melatonin (MEL) is an endogenous hormone that regulates circadian rhythm, immune function and oxidative stress responses. Norepinephrine (NE), an endogenous catecholamine, increases blood pressure through the sympathetic nervous system and is commonly administered intraoperatively or in the clinically ill patient for hemodynamic support ...
Marko MIrza Sahinovic, Ilonka Nadia de Keijzer, Manon Stern, Karin Marianne Vermeulen, Michel Maria Roger Fernand Struys, Anthony Ray Absalom, Johannes Pieter van den Berg, Jaap Jan Vos   +7 more
wiley   +1 more source

Effectiveness and acceptability of cognitive-behavioural therapy delivery formats for obsessive-compulsive disorder: network meta-analysis. [PDF]

Br J Psychiatry
Wang Y, Miguel C, Ciharova M, Amarnath A, Lin J, Zhao R, Toffolo MBJ, Harrer M, Struijs SY, de Wit LM, Cuijpers P.   +10 more
europepmc   +1 more source

A MUC13 Variant Enhances Intestinal Ferric Iron Absorption in Unexplained Hyperferritinemia

Liver International, Volume 46, Issue 11, November 2026.
ABSTRACT Background & Aims Hyperferritinemia frequently remains unexplained despite comprehensive evaluation. We conducted a sequencing‐based exome association study to identify genetic variants associated with plasma ferritin levels in patients with unexplained hyperferritinemia.
Jonas Callet, Yong H. Sheng, Yaowu He, Maël Silva Rodriguez, Céline Chéry, Ramia Safar, Françoise Barbé, Mouni Bensenane, Rosa‐Maria Guéant‐Rodriguez, Fares Namour, Guillaume Gauchotte, Janelle Louise Hancock, Hana Manceau, Thibaud Lefebvre, Dimitri Tchernitchko, Hervé Puy, Timothy H. Florin, Jakob Begun, John D. Hooper, Jean‐Pierre Bronowicki, Michael A. McGuckin, Jean‐Louis Guéant, Abderrahim Oussalah   +22 more
wiley   +1 more source