Results 241 to 250 of about 87,999 (333)
Trajectories of depression across key events in later life: findings from the English Longitudinal Study of Ageing. [PDF]
Br J PsychiatryBeach B, Shim EJ, Iob E, Zaninotto P.
europepmc +1 more source
Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.ABSTRACT Cognitive impairments are important therapeutic targets in epilepsy medication; however, effective pharmacological treatments for epilepsy patients with comorbid cognitive impairment have not been established. Effects of chronic administration of MK‐801 (noncompetitive NMDA receptor inhibitor), memantine (low‐affinity extrasynaptic‐NMDA ...
Motohiro Okada +3 more
wiley +1 more source
AFD thermosensory neurons mediate tactile-dependent locomotion modulation in <i>C. elegans</i>. [PDF]
ElifeRosero M, Bai J.
europepmc +1 more source
British Journal of Developmental Psychology, Volume 44, Issue 2, Page 469-484, June 2026.Abstract Preterm birth is associated with later language impairment and delay. Socio‐economic deprivation is linked to decreased language exposure in early childhood, but it is unknown how prematurity influences this relationship. This study investigated the effects of socio‐economic status and gestational age at birth on language exposure, in a sample
Sinéad O'Carroll +5 more
wiley +1 more source
Healthy Body and Mind Program to Improve Health Outcomes and Reduce Dementia Risk in People With Osteoarthritis: Protocol for a Feasibility and Acceptability Pilot Randomized Controlled Trial. [PDF]
JMIR Res ProtocBurley CV +6 more
europepmc +1 more source
Induction of IL‐9‐producing CD8+ T cells by ascochlorin derivatives
British Journal of Pharmacology, Volume 183, Issue 11, Page 3015-3031, June 2026.A newly synthesised ascochlorin derivative, N184, induces small amounts of IL‐9‐producing CD8+ T cells. N184 improved the survival of CD8+ T cells and enhanced their antitumour activity, partially in an IL‐9‐dependent manner. The antitumour effect was completely dependent on IFNγ secretion rather than the cytotoxic activity of CD8+ T cells.
Natsumi Imano +5 more
wiley +1 more source
The <i>British Journal of Psychiatry</i> affirms its support of drug and alcohol research. [PDF]
Br J PsychiatryRoberts E, Finch E, Lingford-Hughes A.
europepmc +1 more source
British Journal of Pharmacology, Volume 183, Issue 11, Page 2660-2674, June 2026.Abstract Background and Purpose Spleen tyrosine kinase (SYK) has broad biological functions in inflammation and immunity. The orally administered SYK inhibitor BI 894416 was investigated in a single‐rising‐dose Phase I study in healthy volunteers and in a combined single‐ and multiple‐rising‐dose Phase Ib study in patients with mild asthma ...
Saskia Carstensen‐Aurèche +8 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 11, Page 2874-2889, June 2026.Abstract Background and Purpose Overactivation of the alternative pathway (AP) underlies several diseases. Iptacopan is an oral, first‐in‐class, highly potent specific inhibitor of factor B, a key AP protease. Experimental Approach The analysis included data from two phase 1 randomised, volunteer‐blinded, placebo‐controlled studies: Study 1, a single ...
Irina Baltcheva +5 more
wiley +1 more source