Results 251 to 260 of about 87,999 (333)

Inconsistency between serum IgG κ and glomerular IgA λ chain types in proliferative glomerulonephritis with monoclonal deposits successfully treated with daratumumab-based therapy. [PDF]

Medicine (Baltimore)
Chen H, Chen D, Zhang G, Cheng M, Jin J, Niu Z, Zhu R, Guo L, Wang J, Bai Y, Xu J, Cheng Z.   +11 more
europepmc   +1 more source

Fenofibrate potentiates the therapeutic efficacy of EZH2 inhibitors on melanoma via TRIM21‐ and OTUD4‐mediated EZH2 ubiquitination

British Journal of Pharmacology, Volume 183, Issue 11, Page 2675-2694, June 2026.
Background and Purpose EZH2 (enhancer of zeste homologue 2) inhibitors are an emerging class of drugs that target epigenetic regulation. However, their efficacy in solid tumours has been limited, partly due to drug‐induced upregulation of fatty acid synthesis.
Rui Cheng, Yuanjun Tang, Xuedi Cao, Xiaotong Yu, Zhanya Huang, Yunyun Guo, Renjing Jin, Yan Wang, Yang Liu, Lixiang Xue, Yuqing Wang   +10 more
wiley   +1 more source

Relationship between symptoms, sociodemographic factors, and general practice help-seeking in 10 904 adults aged 50 and over. [PDF]

Eur J Public Health
Adam R, Vieira R, Hannaford PC, Martin K, Whitaker KL, Murchie P, Elliott AM.   +6 more
europepmc   +1 more source

Synergistic RU486 and olaparib therapy enhances apoptosis in endometriosis by simultaneously targeting hormonal signalling and DNA repair

British Journal of Pharmacology, Volume 183, Issue 11, Page 2947-2968, June 2026.
Background and Purpose Endometriosis is a chronic, hormone‐dependent disorder characterized by ectopic implantation of endometrial tissue, often accompanied by pain and infertility. Although the progesterone receptor modulator RU486 is effective for pain relief, its impact on lesion regression is limited, possibly due to apoptosis resistance and ...
Yujie Peng, Meng Zhang, Libo Zhu, Wenqiang Qian, Jingjing Yan, Huidi Jiang, Yu Xin, Ying Zhang, Dongli Sun, Weidong Fei, Mengdan Zhao   +10 more
wiley   +1 more source

Evaluating Computerised Assessment of Motor Imitation (CAMI) for identifying autism-specific difficulties not observed for attention-deficit hyperactivity disorder or neurotypical development. [PDF]

Br J Psychiatry
Santra R, Pacheco C, Crocetti D, Vidal R, Mostofsky SH, Tunçgenç B.   +5 more
europepmc   +1 more source

Modulation of KATP channels by diazoxide preserves mitochondrial function and barrier integrity under staurosporine‐induced epithelial stress

British Journal of Pharmacology, Volume 183, Issue 12, Page 3213-3233, June 2026.
Background and Purpose Intestinal barrier dysfunction caused by mitochondrial stress, oxidative damage and apoptosis, are hallmarks of dysbiosis‐associated gastrointestinal (GI) disorders. Staurosporine causes downstream features of dysbiosis‐induced epithelial damage.
Fatima Maqoud, Eleonora Malerba, Simona Drago, Antonella Orlando, Domenica Mallardi, Nicoletta De Lucia, Marina Antonacci, Annamaria Di Turi, Domenico Tricarico, Francesco Russo   +9 more
wiley   +1 more source

Why doesn't neuroimaging work in psychiatry? [PDF]

Br J Psychiatry
McCutcheon RA, Jauhar S, Pillinger T.
europepmc   +1 more source

Understanding CPVT pathogenic mechanisms based on mutation location within RyR2: towards personalized medicine?

The Journal of Physiology, EarlyView.
Jean‐Pierre Benitah, Esther Zorio, Ana María Gómez   +2 more
wiley   +1 more source

Higher sensitivity to ouabain‐induced toxicity in human induced pluripotent stem cell‐derived cardiomyocytes than human adult heart tissue despite similar Na+/K+‐ATPase pump current amplitudes

British Journal of Pharmacology, Volume 183, Issue 11, Page 3093-3110, June 2026.
Abstract Background and Purpose Human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CM) have gained interest as a pharmacological model but their immaturity leads to uncertainty regarding translation. We studied the key player in maintaining ionic homeostasis, the Na+/K+‐ATPase (NKA), in hiPSC‐CM.
Djemail Ismaili, Paavo Virtanen, Junsoo Im, Paul Brunnbauer, Umber Saleem, Muhammed Ikbal Sönmez, Carl Schulz, Margaret Nandudu, Joris Winters, Cristina E. Molina, Johannes Petersen, Monika Stoll, Ulrich Schotten, Arne Hansen, Thomas Eschenhagen, Jussi T. Koivumäki, Torsten Christ   +16 more
wiley   +1 more source

Endocytic protein AP180 assembly domain regulates synaptic vesicle size and release in Caenorhabditis elegans. [PDF]

PLoS Biol
Wang Y, Wu L, Zhang L, Dong Y, Pant A, Liu Y, Bai J.   +6 more
europepmc   +1 more source