Results 271 to 280 of about 87,999 (333)

Thrombospondin‐4 is upregulated in abdominal aortic aneurysm: A vasoprotective response with potential therapeutic relevance

British Journal of Pharmacology, Volume 183, Issue 12, Page 3321-3339, June 2026.
TSP4 is upregulated in human and experimental AAA. TSP4 knockdown accelerated AAA formation and exacerbated both vascular inflammation and remodelling, emphasizing that TSP4 upregulation may represent a protective response against AAA. Our findings suggest that preserving TSP4 could be a useful strategy in the clinical management of AAA.
Laia Blanco‐Casoliva, Lidia Puertas‐Umbert, Judith Alonso, Rafael Almendra‐Pegueros, Saray Varona, Mercedes Camacho, Gemma Arderiu, Lluís Asmarats, Marta Alegret, Jose Martinez‐Gonzalez, Cristina Rodriguez   +10 more
wiley   +1 more source

Anti-VEGF immunotherapy with HEBERSaVax suppresses melanoma growth and metastasis via angiogenesis blockade and enhanced T-cell infiltration. [PDF]

Front Immunol
Morera-Díaz Y, García-Sanmartín J, Canaán-Haden C, Bequet-Romero M, Gonzalez-Moya I, Ayala-Ávila M, Tadic S, Garrido P, Narro-Íñiguez J, Fuentes-Morales D, Bernáldez-Sarabia J, Valdovinos-Navarro BJ, Licea-Navarro AF, Martínez A.   +13 more
europepmc   +1 more source

Enhancing antitumour response to proteasome inhibitors with inhibitors of insulin‐degrading enzyme, a new molecular vulnerability in multiple myeloma

British Journal of Pharmacology, Volume 183, Issue 12, Page 3355-3376, June 2026.
Inhibitors of insulin‐degrading enzyme boost PI cytotoxicity through an increased sensitivity of proteasome to PI inhibitors, induction of ISR, DNA damage and Myc down‐regulation. They overcome PI resistance in vitro and induce tumour regression in vivo.
Laetitia Lesire, Rebecca Deprez‐Poulain, Damien Bosc, Florence Leroux, Valerie Landry, Sarah Ourabah, Morgane Tardy, Clara Maillard, Ronan Gealageas, Julie Dumont, Adrien Herledan, Sandrine Warenghem, Manon Cruette, Celine Lenglart, Alexandre Biela, Catherine Piveteau, Eva De Smedt, Catharina Muylaert, Wenguang Liang, Elvira Garcia De Paco, Elina Alaterre, Sara Ovejero, Nicolas Robert, Fabien Delahaye, Wei‐Jen Tang, Peter van Endert, Elke De Bruyne, Jérôme Moreaux, Benoit Deprez   +28 more
wiley   +1 more source

Online speech and communal conflict: Evidence from India. [PDF]

PNAS Nexus
Schutte S, Karell D, Barrett R.
europepmc   +1 more source

Rate of MGUS Progression to Haematological Malignancies: A Systematic Review

European Journal of Haematology, Volume 116, Issue 6, Page 889-906, June 2026.
ABSTRACT Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic pre‐cancerous condition that precedes plasma cell dyscrasias, including multiple myeloma (MM). Current clinical guidelines report that MGUS's rate of malignant progression to haematological malignancy (HM) is ~1% per year; however, reported rates have varied widely ...
Stephen James Quinn, Chris Cardwell, Lesley Ann Anderson, Charlene McShane   +3 more
wiley   +1 more source

The IUPHAR/BPS Guide to PHARMACOLOGY in 2026. [PDF]

Nucleic Acids Res
Harding SD, Armstrong JF, Faccenda E, Southan C, Alexander SPH, Davenport AP, Spedding M, Davies JA.   +7 more
europepmc   +1 more source

Atomic Layer Deposition of Disordered p‐Type SnO Using a Heteroleptic Tin(II) Precursor: Influence of Disorder on P‐Channel SnO Thin‐Film Transistor Characteristics

Advanced Electronic Materials, Volume 12, Issue 9, 11 May 2026.
Disordered p‐type SnO thin‐films are deposited via atomic layer deposition using a novel heteroleptic precursor. These films enable low‐temperature fabrication of thin‐film transistors with excellent stability and mobility. Their potential compatibility with flexible substrates and integration with n‐type IGZO transistors makes them candidates for ...
Benjamin J. Peek, Kham Man Niang, Benjamin McMitchell, Heath Bagshaw, Karl Dawson, Adrian Gardner, Babak Bakhit, James D. Parish, Oliver W. S. Clark, Joe C. Goodall, Andrew Brookes, Satyajit Das, Feras Alkhalil, Andrew L. Johnson, Andrew J. Flewitt, Paul R. Chalker   +15 more
wiley   +1 more source

Modulation of SAL retrograde signalling promotes yield and water productivity responses in dynamic field environments. [PDF]

New Phytol
Bowerman AF, Moore M, Yadav A, Zhang J, Mortimer MD, Plšková Z, Tee EE, Au EK, Collinge DP, Estavillo GM, Howitt CA, Chan KX, Rebetzke GJ, Pogson BJ.   +13 more
europepmc   +1 more source

Low Percent Copper Doping Limits Bacterial Adhesion on Fluorapatite‐Based Bone Scaffolds

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 5, May 2026.
ABSTRACT Natural and engineered bone grafts are widely used in orthopedic and dental reconstruction; however, infection remains a persistent clinical challenge. Fluorapatite (FAp) is a chemically stable and osteoconductive bone substitute, but it lacks inherent antimicrobial properties. Copper (Cu), known for its potent antibacterial activity, could be
Pooya Elahi, Samantha K. Steyl, Alec Griffin, James Peter Beck, Jay Agarwal, Jill Shea, Sujee Jeyapalina   +6 more
wiley   +1 more source