Results 181 to 190 of about 2,000,486 (258)

Psychological insights for coping with embarrassment in clinical medicine

Journal of Hospital Medicine, EarlyView.
Donald A. Redelmeier, Jada Roach
wiley   +1 more source

Living with the Unknown: Intolerance of Uncertainty in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) is marked by pervasive uncertainty due to fluctuating motor and non‐motor symptoms, variable treatment response, and an unpredictable clinical course. Intolerance of uncertainty (IU), a tendency to perceive ambiguity as threatening and respond with worry, avoidance, or decisional paralysis, may be ...
Bradley McDaniels, Gregory M. Pontone, Kuhan Pushparatnam, Indu Subramanian   +3 more
wiley   +1 more source

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

Lysosomal Expression Profile in Plasma Associates with Disease Severity in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is a clinically and biologically heterogeneous neurodegenerative disorder, driven by multiple mechanisms among which are lysosomal and mitochondrial dysfunction. Here, we explored blood‐based lysosomal and mitochondrial profiles in relation to PD diagnosis and severity.
Janna van Wetering, Manon M. van Ingen, Evelien Timmermans, Sjors G.J.G. in't Veld, Henk W. Berendse, Charlotte E. Teunissen, Wilma D.J. van de Berg   +6 more
wiley   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

From disengagement coping to academic self-efficacy: the conditional role of emotional competence in STEM students. [PDF]

Front Psychol
Bulgac A, Gonța I, Bratu IR.
europepmc   +1 more source

Digital surveillance of animals and nature recovery

People and Nature, EarlyView.
Abstract Digital surveillance technologies (DSTs) are widely applied in nature recovery for their potential to generate novel data on species and ecosystems through digital tracking, automation (e.g. from hazardous locations) and from newly recruited citizen scientists.
William M. Adams
wiley   +1 more source

Diagnostic performance of AI-powered prostate MRI against biopsy ground truth: quasi-continuous risk scoring versus fixed PI-RADS thresholds. [PDF]

Cancer Imaging
Bayerl N, Appel J, Schmidt M, Cavallaro A, Grimm R, von Busch H, Wullich B, Hartmann A, Schlicht M, Uder M, May MS, Ellmann S.   +11 more
europepmc   +1 more source

Belief and the beast: Religion and attitudes towards tigers in Central India

People and Nature, EarlyView.
Abstract Human perceptions of wildlife are critical to shaping conservation outcomes, particularly in landscapes where people coexist with large carnivores. Religion, a deeply rooted sociocultural force, remains underexplored in the context of human–wildlife conflict.
Sathvika Krishnan, Poonam Dhanwatey, Harshwardhan Dhanwatey, Andrew Gosler, Claudio Sillero‐Zubiri   +4 more
wiley   +1 more source

Early prediction of late-pregnancy hypertriglyceridemia in women with gestational diabetes: development and internal validation of a clinical risk model. [PDF]

Front Endocrinol (Lausanne)
Zhao Y, Zhang J, Jin X.
europepmc   +1 more source