Results 61 to 70 of about 2,777,051 (310)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Black-start strategy of distribution network considering photovoltaic output volatility and micro-grid synergy

Diance yu yibiao
The fluctuation of photovoltaic output will cause the restored load to outage again. It is significant to exploit the dispatching resources of micro-grid to reduce load blackout loss of distribution network black-start and resist the risk of load loss ...
ZHONG Hao, FANG Chen, LI Shichun, CHEN Zitong   +3 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Start-up scheme for converter station of MMC-HVDC based on single-clamp sub-module using in grid black start

The Journal of Engineering, 2018
Single-clamp sub-module (SCSM) combining the cost and technological advantages has become one of the next modular multilevel converter (MMC) sub-module topologies in response to DC fault aspect.
ChaoLiang Wang, WenTao Lv, Yi Lu, Feng Xu, Peng Qiu   +4 more
doaj   +1 more source

Being Anal About the Rules: How digital media and gamification redefined the sexual practices and culture of the MSM community [PDF]

, 2018
Developing technologies, digital media and mobile internet access have allowed members of the MSM community the opportunity to integrate their lives more fully into a world once dominated by exclusively straight places and communities - the change ...
Marshall, Conor
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Optimization of Power System Black Start partition Target Network Taking into Account the Black Start Space-Time Support Capability of New Energy Station

Zhongguo dianli
Taking into account the spatiotemporal support capacity of new energy station black start, a target network optimization method for power system black-start zoning is proposed to improve unconventional security defense ability of the new power system ...
Ruixin WANG, Jiguang SUN, Yan LIU, Lun CHENG, Ting XU, Guanghui SUN   +5 more
doaj   +1 more source