Results 41 to 50 of about 93,835 (304)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Photograph of trained bear with handler for the Zanesville Big Bear store [PDF]
, 1948 Black and white photograph of trained bear with handler for the Zanesville big bear store at 160 North Street, Zanesville, Ohio. This photograph was taken in June of 1948.
Big Bear
core
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Cleveland avenue bear promotion [PDF]
, 1954 Black and white photograph of the Big Bear exterior located at 3515 Cleveland Ave. Columbus, Ohio. Children enjoyed going to the store with their parents because a trained bear was caged near the entrance and did tricks for those who stopped to watch ...
Big Bear
core
Revista Mexicana de Biodiversidad, 2013 Black bears (Ursus americanus) are considered endangered in Mexico. In northern Mexico, bears are considered responsible for preying on livestock, damaging private property, and crops; therefore they are killed to protect locals’ livelihoods. There is a
Luis Antonio Juárez Casillas +1 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Men on horseback at Big Bear Farms [PDF]
, 1962 Black and white photograph of Big Bear stores President, Wayne E. Brown, at Big Bear Farms in Powell, Ohio. In 1934, an innovation in food retailing was introduced in Columbus when Wayne E. Brown opened the first self-service supermarket in central Ohio.
Big Bear
core
The role of human outdoor recreation in shaping patterns of grizzly bear-black bear co-occurrence.
PLoS ONE, 2018 Species' distributions are influenced by a combination of landscape variables and biotic interactions with other species, including people. Grizzly bears and black bears are sympatric, competing omnivores that also share habitats with human ...
Andrew Ladle +3 more
doaj +1 more source
Predicting Black Bear Activity at Backcountry Campsites in Bryce Canyon National Park, Utah
Human-Wildlife Interactions, 2019 Developing the capacity to predict black bear (Ursus americanus; bear) activity in a diversity of habitats will help conserve bear populations and their habitats and minimize human–bear conflicts.
Wesley G. Larson, Tom Smith
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source