Results 41 to 50 of about 104,370 (268)

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Multimessenger Probes of Supermassive Black Hole Spin Evolution

The Astrophysical Journal
Using the semianalytic model Serotina , we investigate the cosmic spin evolution of supermassive black holes (SMBHs) incorporating recent results from general-relativistic magnetohydrodynamics simulations of spin-down from relativistic jets.
Angelo Ricarte, Priyamvada Natarajan, Ramesh Narayan, Daniel C. M. Palumbo   +3 more
doaj   +1 more source

Association Between Motor Pathway Damage and Motor Deficit in Upper and Lower Limb in People With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corticospinal tract damage is common in people with MS, but the degree of clinical symptoms varies. We hypothesize that corticospinal tract lesions are more extensive and severe in people with MS with motor impairments in both upper and lower limbs.
Mathilde Liffran, Malo Gaubert, Alice Dufey, Elise Bannier, Audrey Rico, Jean‐Christophe Ferré, Raphaël Chouteau, Laure Michel, Emmanuelle Le Page, Virginie Callot, Bertrand Audoin, Sarah Demortière, Benoît Combès, Anne Kerbrat   +13 more
wiley   +1 more source

Accessing a New Population of Supermassive Black Holes with Extensions to the Event Horizon Telescope

The Astrophysical Journal
The Event Horizon Telescope (EHT) has produced resolved images of the supermassive black holes (SMBHs) Sgr A* and M87*, which present the largest shadows on the sky.
Xinyue Alice Zhang, Angelo Ricarte, Dominic W. Pesce, Michael D. Johnson, Neil Nagar, Ramesh Narayan, Venkatessh Ramakrishnan, Sheperd Doeleman, Daniel C. M. Palumbo   +8 more
doaj   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Jet Archaeology and Forecasting: Image Variability and Magnetic Field Configuration

The Astrophysical Journal
We investigate how magnetic field variations around accreting black holes (BHs) on event horizon scales affect the morphology of magnetically driven jets on larger scales.
Yuh Tsunetoe, Ramesh Narayan, Angelo Ricarte   +2 more
doaj   +1 more source

First law of black hole thermodynamics and the weak cosmic censorship conjecture for Kerr–Newman Taub–NUT black holes

European Physical Journal C: Particles and Fields, 2023
Stimulated by the recent researches of black hole thermodynamics for black hole with Newman–Unti–Tamburino (NUT) parameter, we investigate the thermodynamics and weak cosmic censorship conjecture for a Kerr–Newman Taub–NUT black hole.
Si-Jiang Yang, Wen-Di Guo, Shao-Wen Wei, Yu-Xiao Liu   +3 more
doaj   +1 more source

Connecting Black Holes and Black Strings [PDF]

Physical Review Letters, 2005
Static vacuum spacetimes with one compact dimension include black holes with localised horizons but also uniform and non-uniform black strings where the horizon wraps over the compact dimension. We present new numerical solutions for these localised black holes in 5 and 6-dimensions.
Kudoh, Hideaki, Wiseman, Toby
openaire   +3 more sources

Stem Cell Transplantation in Friedreich Ataxia: Cure for Leukemia but No Effect on Neurological Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Friedreich Ataxia (FRDA) is a neurodegenerative disorder of children and young adults associated with cardiomyopathy and other systemic complications. We report a 10‐year‐old girl who presented simultaneously with Acute Myelogenous Leukemia and FRDA who was successfully treated for her leukemia with allogeneic hematopoietic stem cell ...
Alexandra Gitman, Niyati Bhandari, Maria Castellaro, Kim Schadt, María Cancio, David R. Lynch   +5 more
wiley   +1 more source

Mildly Super-Eddington Accretion onto Slowly Spinning Black Holes Explains the X-Ray Weakness of the Little Red Dots

The Astrophysical Journal
JWST has revealed a population of low-luminosity active galactic nuclei at z > 4 in compact, red hosts (the “Little Red Dots,” or LRDs), which are largely undetected in X-rays.
Fabio Pacucci, Ramesh Narayan
doaj   +1 more source