Results 31 to 40 of about 729,890 (281)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Accuracy and reproducibility of a single‐pose image‐to‐robot registration method for mobile C‐arm cone beam CT guided histotripsy

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Histotripsy is a focal tumor therapy that utilizes focused ultrasound (US) to mechanically destroy tissue. To overcome visualization limitations of diagnostic US‐guidance, C‐arm cone beam CT (CBCT)‐guided histotripsy is being developed, for which a mobile C‐arm could increase accessibility. CBCT‐guided histotripsy uses a phantom with a
Grace M. Minesinger, Paul F. Laeseke, Katrina L. Falk, Claire E. Hennen, Michael A. Speidel, Martin G. Wagner   +5 more
wiley   +1 more source

Phantom Energy Accretion onto Black Holes in Cyclic Universe

, 2008
Black holes pose a serious problem in the cyclic or oscillating cosmology. It is speculated that, in the cyclic universe with phantom turnarounds, black holes will be torn apart by the phantom energy before turnaround before they can create any problems.
Cheng-Yi Sun, P. Martin-Moruno, R. C. Tolman   +2 more
core   +3 more sources

Validity and Reliability of Clinical and Patient‐Reported Outcomes in Multisystem Proteinopathy 1

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Valosin‐containing protein (VCP)‐associated multisystem proteinopathy 1 (MSP1) is caused by variants in the VCP gene. MSP1 results in various phenotypes including progressive myopathy, Paget's disease of bone, frontotemporal dementia, amyotrophic lateral sclerosis, and parkinsonism, among others.
Lindsay N. Alfano, Megan A. Iammarino, Natalie F. Reash, Linda P. Lowes, Lindsay Pietruszewski, Kathleen Adderley, Lauren Humphrey, Audrey B. Knight, Christopher L. Steiner, Melissa A. Smith, Zarife Sahenk, Anne M. Connolly, Momen Almomen, Eleonora S. D'Ambrosio, Nathan Peck, Allison Peck   +15 more
wiley   +1 more source

Large rotating AdS black holes from fluid mechanics

, 2008
We use the AdS/CFT correspondence to argue that large rotating black holes in global AdS(D) spaces are dual to stationary solutions of the relativistic Navier-Stokes equations on S**(D-2).
Bhattacharyya, Sayantani, Lahiri, Subhaneil, Loganayagam, R., Minwalla, Shiraz   +3 more
core   +1 more source

SARS‐CoV‐2 Is Linked to Brain Volume Loss in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The impact of SARS‐CoV‐2 infection on brain and spinal cord pathology in patients with multiple sclerosis (pwMS) remains unclear. We aimed to describe changes in brain lesion activity and brain and spinal cord volumes following SARS‐CoV‐2 infection.
Tomas Uher, Dominika Stastna, Ingrid Menkyova, Vaclav Capek, Jiri Lindner, Petra Nytrova, Jan Krasensky, Eliza Varju, Miguel D'haeseleer, Eva Kubala Havrdova, Dana Horakova, Manuela Vaneckova, Niels Bergsland   +12 more
wiley   +1 more source

Thermodynamics of a class of regular black holes with a generalized uncertainty principle

, 2018
In this article, we present a study on thermodynamics of a class of regular black holes. Such a class includes Bardeen and Hayward regular black holes. We obtained thermodynamic quantities like the Hawking temperature, entropy, and heat capacity for the ...
Maluf, R. V., Neves, Juliano C. S.
core   +1 more source

A Perspective on Powder Metallurgy and Additive Manufacturing of High‐Nitrogen Alloyed Stainless Steels

Advanced Engineering Materials, EarlyView.
This perspective article explores an innovative powder metallurgical approach to producing high‐nitrogen steels by utilizing a mixture of stainless steel and Si3N4. This mixture undergoes hot isostatic pressing followed by direct quenching. The article also examines adapting this method to laser powder bed fusion (PBF‐LB/M) to overcome nitrogen ...
Louis Becker, Felix Radtke, Jonathan Lentz, Simone Herzog, Christoph Broeckmann, Sebastian Weber   +5 more
wiley   +1 more source

Macroscopic Black Holes, Microscopic Black Holes and Noncommutative Membrane

, 2003
We study the stretched membrane of a black hole as consisting of a perfect fluid. We find that the pressure of this fluid is negative and the specific heat is negative too.
Hawking S, Maldacena J, Miao Li, Thorne K S, Yoneya T, Yoneya T   +5 more
core   +5 more sources

Enhanced Fog Water Harvesting on Superhydrophobic Steel Meshes

Advanced Engineering Materials, EarlyView.
Fog harvesting using mesh designs offers a sustainable solution to water scarcity. This study highlights key considerations for fog harvesting research and develops a methodology for a standardized protocol reflecting fog characteristics and environmental conditions.
Pegah Sartipizadeh, Mohammad Reza Mohammadizadeh, Carlo Antonini, Raziyeh Akbari   +3 more
wiley   +1 more source