Results 51 to 60 of about 812,429 (344)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

open access: yesFEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy   +14 more
wiley   +1 more source

Maximal forces and thermodynamic quantities of specific black holes in modified theories of gravity

open access: yesNuclear Physics B, 2023
In this work, we explore the maximum force conjecture and thermal fluctuations for different black holes such as the brane-world black hole, de Rham-Gabadadze-Tolley black hole, Black-Bounce Reisner-Nordström black hole, and renormalization group ...
Abdul Jawad, Usman Zafar
doaj  

Dilatonic BTZ black holes with power-law field

open access: yesPhysics Letters B, 2017
Motivated by low energy effective action of string theory and numerous applications of BTZ black holes, we will consider minimal coupling between dilaton and nonlinear electromagnetic fields in three dimensions.
S.H. Hendi   +3 more
doaj   +1 more source

Large rotating AdS black holes from fluid mechanics

open access: yes, 2008
We use the AdS/CFT correspondence to argue that large rotating black holes in global AdS(D) spaces are dual to stationary solutions of the relativistic Navier-Stokes equations on S**(D-2).
Bhattacharyya, Sayantani   +3 more
core   +1 more source

Non-uniqueness, Counterrotation, and Negative Horizon Mass of Einstein-Maxwell-Chern-Simons Black Holes [PDF]

open access: yes, 2006
Stationary black holes in 5-dimensional Einstein-Maxwell-Chern-Simons theory possess surprising properties. When considering the Chern-Simons coefficient $\lambda$ as a parameter, two critical values of $\lambda$ appear: the supergravity value $\lambda_{\
Ascher U.   +4 more
core   +3 more sources

Phantom Energy Accretion onto Black Holes in Cyclic Universe

open access: yes, 2008
Black holes pose a serious problem in the cyclic or oscillating cosmology. It is speculated that, in the cyclic universe with phantom turnarounds, black holes will be torn apart by the phantom energy before turnaround before they can create any problems.
Cheng-Yi Sun   +2 more
core   +3 more sources

Position‐dependent offset corrections for ring applicator reconstruction in cervical cancer brachytherapy

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Due to the tight curvature in their design, ring applicators are usually associated with large positioning errors. The standard practice to correct for these deviations based on global offsets may not be sufficient to comply with the recommended tolerance.
Leon G. Aldrovandi   +3 more
wiley   +1 more source

Mass Functions of Supermassive Black Holes across Cosmic Time

open access: yesAdvances in Astronomy, 2012
The black hole mass function of supermassive black holes describes the evolution of the distribution of black hole mass. It is one of the primary empirical tools available for mapping the growth of supermassive black holes and for constraining ...
Brandon C. Kelly, Andrea Merloni
doaj   +1 more source

QCD and spin effects in black hole airshowers [PDF]

open access: yesPhys.Rev.D76:044005,2007, 2007
In models with large extra dimensions, black holes may be produced in high-energy particle collisions. We revisit the physics of black hole formation in extensive airshowers from ultrahigh-energy cosmic rays, focusing on collisional QCD and black hole emissivity effects. New results for rotating black holes are presented.
arxiv   +1 more source

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