Results 81 to 90 of about 6,064,014 (277)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Filtering out mislabeled training instances using black-box optimization and quantum annealing

Scientific Reports
This study proposes an approach for removing mislabeled instances from contaminated training datasets by combining surrogate model-based black-box optimization (BBO) with postprocessing and quantum annealing. Mislabeled training instances, a common issue
Makoto Otsuka, Kento Kodama, Keisuke Morita, Masayuki Ohzeki   +3 more
doaj   +1 more source

Thermodynamics of three-dimensional black holes via charged particle absorption

Physics Letters B, 2016
We have shown that changes occur in a (2+1)-dimensional charged black hole by adding a charged probe. The particle increases the entropy of the black hole and guarantees the second law of thermodynamics.
Bogeun Gwak, Bum-Hoon Lee
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Erratum to: Coarse-graining black holes out of equilibrium with boundary observables on time slice

Journal of High Energy Physics
A correction to this paper has been published: https://doi.org/10.1007/JHEP05(2024 ...
Daichi Takeda
doaj   +1 more source

Reimagining Religious Education for Young, Black, Christian Women: Womanist Resistance in the Form of Hip-Hop

Religions, 2018
How might the black church and womanist scholarship begin to re-imagine religious education in ways that attends more deliberately to the unique concerns and interests of younger black, Christian women? Throughout the history of the black church, despite
Tamara Henry
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Station Black-Out Analysis with MELCOR 1.8.6 Code for Atucha 2 Nuclear Power Plant

Science and Technology of Nuclear Installations, 2012
A description of the results for a Station Black-Out analysis for Atucha 2 Nuclear Power Plant is presented here. Calculations were performed with MELCOR 1.8.6 YV3165 Code.
Analia Bonelli, Oscar Mazzantini, Martin Sonnenkalb, Marcelo Caputo, Juan Matias García, Pablo Zanocco, Marcelo Gimenez   +6 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

“No Future for Black People in Chicago”: Out-Migration as Slow-Motion Disaster

Socius
From 2000 to 2019, the number of Black residents in Chicago dropped 25 percent. In this study, we sought to understand how Black Chicagoans make meaning of out-migration, their desires for the city and its future, and the factors they use to navigate ...
Eve L. Ewing, Samhitha Krishnan, Brianna Lawrence   +2 more
doaj   +1 more source