Results 201 to 210 of about 183,056 (297)

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Race-Specific Impact of Telehealth Advance Care Planning on Cost of Dementia: A Cost Prediction Study. [PDF]

Int J Environ Res Public Health
Reed PS, Kim Y, Shen JJ, Kosaraju S, Kang M, Carson J, Chaudhry II, Kim S, Jeong C, Hwang Y, Yoo JW.   +10 more
europepmc   +1 more source

SpaMode: A Broadly Applicable Framework for Deciphering Spatial Multi‐Omics Using Multimodal Mixture of Disentangled Experts

Advanced Science, EarlyView.
SpaMode introduces a versatile framework for spatial multi‐omics integration across vertical, horizontal, and mosaic scenarios. By disentangling modality‐invariant and variant features through a mixture‐of‐experts mechanism, it adaptively reconfigures spatially heterogeneous signals.
Xubin Zheng, Xinlei Huang, Xiang Zhou, Dian Meng, Ziyue Qiao, Zhiyuan Yuan, Lixin Cheng   +6 more
wiley   +1 more source

Citric acid-modulated carbon dots derived from black tea waste for multifunctional food packaging: anti-counterfeiting and UV-protective preservation. [PDF]

RSC Adv
Liu Y, Li J, Xiao Y, Chen Y, Zhou Y, Zhou F, Zhu B, Jiang W, Chen X, Li G.   +9 more
europepmc   +1 more source

Rewiring NADH Metabolism Through NQO1‐Mediated Redox Cycling for Targeted Follicular Lymphoma Therapy

Advanced Science, EarlyView.
ABSTRACT Follicular lymphoma (FL) remains an incurable B‐cell malignancy with high relapse rates, and conventional therapies are often limited by significant toxicity, highlighting the need for novel treatments. We identified that FL exhibits markedly low expression of NAD(P)H: quinone oxidoreductase 1 (NQO1), a key enzyme required for activating ...
Jinxing Zhang, Ziqi Wang, Ye Weng, Yulin Fu, Yuelong Jiang, Beilin Zhuang, Wenzi Zeng, Xiangchun Zhang, Bing Xu, Jie Zha, Hongjun Zhuang   +10 more
wiley   +1 more source

Structural enzymology of a Fusarium graminearum aldehyde oxidase reveals a distinct active-site and reactivity versus its paralog galactose oxidase. [PDF]

Biochem J
Fong JK, Mazo L, Nairn AK, Lorizolla Cordeiro R, Mathieu Y, Chen YS, Rovira C, Walton PH, Van Petegem F, Brumer H.   +9 more
europepmc   +1 more source

SERRATE Regulates Floral Meristem Activity by Antagonizing SHOOT MERISTEMLESS and Repressing Cytokinin Signaling

Advanced Science, EarlyView.
Floral meristem (FM) activity is crucial for the initiation of floral organs. In this study, SE represses IPT7 expression and cytokinin signaling via both the miR171c‐5p–KNAT2 and miR164c–CUC1/2–KNAT2 regulatory modules, thereby repressing FM activity. In contrast, STM induces both KNAT2 and IPT7 expression.
Wen Yang, Yiting Wang, Yuxin You, Zhiyue Wu, Dongbao Li, Xin Wang, Yongsheng Chang, Hang Zhao, Tao Zhu, Dijun Chen, Wei Chen, Bo Sun   +11 more
wiley   +1 more source

Increasing digital media visibility and tourism messaging promote US National Park system integration. [PDF]

PNAS Nexus
Petersen AM, Arroyave F, Shackelton S, Jenkins JS.   +3 more
europepmc   +1 more source

Rational Design of Weakly‐Solvating Molecules for Salt‐In‐Pre‐Ionic‐Liquid Electrolytes for Li Metal Batteries

Advanced Science, EarlyView.
The weakly‐solvating TFMSPyr electrolyte tailors the Li+ solvation structure by suppressing solvent coordination and promoting anion‐dominated solvation. This unique solvation environment induces preferential anion decomposition at electrode interfaces, forming robust inorganic rich S/CEI.
Bishnu P. Thapaliya, Vaidyanathan Sethuraman, Naresh C. Osti, Arvind Ganesan, K. Shawn Reeves, Michael J. Zachman, Albina Y. Borisevich, Harry M. Meyer III, Xiao‐Guang Sun, Eugene Mamontov, Lei Cheng, Sheng Dai   +11 more
wiley   +1 more source

Gradient descent in materia through homodyne gradient extraction. [PDF]

Nat Commun
Boon MN, Cassola L, Ruiz Euler HC, Chen T, van de Ven B, Alegre Ibarra U, Bobbert PA, van der Wiel WG.   +7 more
europepmc   +1 more source