Results 241 to 250 of about 183,056 (297)

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source

Explainable and interpretable models for predicting early-onset hypertension in the Tlalpan 2020 cohort. [PDF]

Front Digit Health
Gutiérrez-Esparza G, Martínez-García M, Amezcua-Guerra LM, Montes Rivera M, Hernández-Lemus E.   +4 more
europepmc   +1 more source

AI‐Physics‐Experiment Trinity for Integrated Protein Dynamics Modeling

Advanced Science, EarlyView.
This review unites experiments, physics‐based simulations, and AI as a synergistic triad for protein dynamics modeling. It highlights integrative strategies, resolves sampling and forcefield bottlenecks, and outlines challenges and future directions for accurate, interpretable conformational ensemble prediction.
Chen Shi, Minying Low, Peng Xiu, Kresten Lindorff‐Larsen, Yong Wang   +4 more
wiley   +1 more source

The effect of disruptive protests on public opinion. [PDF]

PNAS Nexus
Vandeweerdt C.
europepmc   +1 more source

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

From mental health detention to health systems reform: Co-producing policy and practice recommendations with Black men, their communities, and health and social care professionals. [PDF]

PLOS Ment Health
Craig E, Leah C, Dixon J, Bergqvist A, Brodrick I, Best D, Heyes K, Duxbury J, Haines-Delmont A.   +8 more
europepmc   +1 more source

The public health consequences of officer discretion in arrests affecting LGBTQ+ communities in the United States: a scoping review. [PDF]

Health Justice
Rubalcava Hernandez EJ, Bayhi JL, Herron C, Dew S, Margaritis W, DeBerry LS, Nava M.   +6 more
europepmc   +1 more source

Bumblebees locate goals in 3D with absolute height estimation from ventral optic flow.

J Exp Biol
Sonntag A, Egelhaaf M, Bertrand OJN, Lihoreau M.   +3 more
europepmc   +1 more source

Rethinking well-being in capitalist value-centered societies: football in Japan as contemporary capitalistic ritual. [PDF]

Front Sports Act Living
Razgui Y.
europepmc   +1 more source

From platform carnival to official discourse: How "truth" is produced in Chinese online news. [PDF]

PLoS One
Li J, Hu S.
europepmc   +1 more source