Results 131 to 140 of about 184,178 (309)

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

FEATURES OF BUSINESS COMMUNICATIONS IN THE SPHERE OF PUBLIC ADMINISTRATION

Публічне управління та регіональний розвиток
The article is devoted to the urgent problem of analyzing business communications at different levels of public administration as a way of improving the quality and accessibility of public services.
Viktoriia Andriiash, Svitlana Verba
doaj   +1 more source

Europe's Black Sea Dimension. CEPS Paperback. June 2002 [PDF]

, 2002
The Organisation for Black Sea Economic Cooperation (BSEC) brings together one of the most diverse regions in the world. Formed following the end of the Cold War from two opposing political and military blocs, the BSEC serves as an exemplary model of the
Adams, Terry D., Emerson, Michael, Mee, Lawrence David, Vahl , Marius   +3 more
core  

Lithology, biostratigraphy, and geochemistry of the Black Sea sediments, DSDP Leg 42 (pt. 2) data

, 1980
The monograph presents results of deep-sea drilling in the Black Sea carried out in 1975. Detailed lithological, biostratigraphic and geochemical studies of Miocene-Holocene sediments have been carried out by specialists from institutes of the USSR ...
Shneider, G F, Kazimir M Shimkus (6967715), Chernova, Tatyana G, Mukhina, Valentina V, G F Shneider (7922042), Valentina V Mukhina (6965780), Zhigunov, Alexander S, Trimonis, Egidius S, Vladimir M Kuptsov (6959669), Tanzilya R Ivanova (7922045), Anastasiya P Zhuse (7922066), Egidius S Trimonis (6962435), Moskalev, Anatoly S, Zhuse, Anastasiya P, Geodekyan, Artyom A, Ivanova, Tanzilya R, Artyom A Geodekyan (7922048), Krylov, Alexey A, Shimkus, Kazimir M, Alexander S Zhigunov (6974033), Kuptsov, Vladimir M, Alexey A Krylov (6958568), Anatoly S Moskalev (6970988), Tatyana G Chernova (7922051)   +23 more
core   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Analysis of Carotenoids, Vitamins and Folates in Traditional Foods from Black Sea Area [PDF]

, 2011
Nowadays, consumers are much more aware of nutritional composition and show especially interest in compounds with putative health benefits. Therefore, in the last few years, great attention has been devoted to the study of bioactive compounds in order to
Sanches-Silva, A., Costa, H.S., D’Antuono, L.F., Albuquerque, T.G., Santos, M., Flores, A.C., Ribeiro, T., Valente, A., Finglas, P., on behalf of the BaSeFood Black Sea area partners   +9 more
core  

Escalating Rivalries and Diverging Interests: Prospects for Stability and Security in the Black Sea Region

, 2010
The Black Sea region is increasingly becoming a priority on the international agenda. In fact a regional approach is emerging as actors understand that common problems need to be addressed jointly.
Çelikpala, Mitat
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source