Results 111 to 120 of about 184,178 (309)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

After the Crimean Crisis: Towards a Greater Russian Maritime Power in the Black Sea

, 2014
The modernization of the Black Sea Fleet currently underway is believed to be one of the most ambitious parts of the Russian State Arms Procurement programme 2011-2020.
Delanoe, Igor
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

LEGAL PRINCIPLES OF PERSONNEL MANAGEMENT IN THE CIVIL SERVICE IN THE CONTEXT OF THE DEVELOPMENT OF THE INFORMATION SOCIETY

Публічне управління та регіональний розвиток
The article analyzes the regulatory and legal regulation of personnel management in the civil service in the context of the development of the information society.
Anastasiia Shulha, Valentyna Serhiienko
doaj   +1 more source

Traditional foods of Black Sea Countries [PDF]

, 2011
INTRODUCTION: Traditional dietary patterns, generally beneficial to health as judged over time, should be promoted beyond the native country’s borders. Scientific data is a prerequisite for the successful promotion of a sustainable diet.
Dilis, V., Costa, H.S., D’Antuono, L.F., Vasilopoulou, E., Finglas, P., Trichopoulou, A., on behalf of the BaSeFood Black Sea area partners   +6 more
core  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

SOCIAL POLICY IN THE FIELD OF ARCHITECTURAL ACCESSIBILITY FOR PEOPLE WITH LIMITED MOBILITY: INTERNATIONAL EXPERIENCE AND OPPORTUNITIES FOR ADAPTATION IN UKRAINE

Публічне управління та регіональний розвиток
The article analyzes the experience of foreign countries in the field of architectural accessibility for people with limited mobility and the possibilities of its adaptation in Ukraine.
Svitlana Surgova, Olena Faichuk
doaj   +1 more source

The Oxidation of H2S with O2 in the Black Sea

The oxidation of H2S with O2 in Black Sea waters was measured at 25°C. The measurements were made on mixtures of deep and surface waters. The oxidation rates were found to be ten times faster than the rates for surface seawater (Black Sea and Gulf Stream)
Millero, Frank J
core   +1 more source