Results 61 to 70 of about 1,420,693 (238)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
DATA ACQUISITION SYSTEM FOR PROSTHETIC MOTION SIMULATION
Автоматизация технологических и бизнес-процессов. The human hand, with its complex sensory capabilities, is an integral part of our daily interaction with the world. This remarkable organ contains a variety of natural sensors that enrich our experience by allowing us to perceive touch, determine ...
N. Hiulmamedov +2 more
doaj +1 more source
Express forecast of the radiation stress to the population from NPP gazoaerozol emissions NPP [PDF]
Ядерна фізика та енергетика, 2014 Express method of forecast evaluation values of dose load to the population from the territories under the simultaneous influence of radionuclide pollutants natural and artificial origin was proposed. Based on the results of radioecological research in
L. I. Grygorieva +2 more
doaj
The impact of stressful life events on the functionality of patients with schizophrenia
Psychiatry and Clinical Psychopharmacology, 2021 Objective: In this study, clinical symptoms, functional recovery levels and stressful life events of patients with schizophrenia were evaluated to investigate the relationship between life events and functional recovery.
Gizem Güneş +3 more
doaj
, 2014 It was a bright, brisk day. The foaming sea crashed gaily against shining rocks. The wind blew high and strong. My hair was torn back from my face; my wet face, so clean and free. I was free. The wind and the sea and I were free .. free .. free. Life had
Kessler, Mary Alice
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Cenozoic evolution of the eastern Black Sea: a test of depth-dependent stretching models [PDF]
, 2008 Subsidence analysis of the eastern Black Sea basin suggests that the stratigraphy of this deep, extensional basin can be explained by a predominantly pure-shear stretching history.
Edwards, Glyn R.H. +6 more
core +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source