Results 81 to 90 of about 126,210 (262)

LEGAL PRINCIPLES OF PERSONNEL MANAGEMENT IN THE CIVIL SERVICE IN THE CONTEXT OF THE DEVELOPMENT OF THE INFORMATION SOCIETY

Публічне управління та регіональний розвиток
The article analyzes the regulatory and legal regulation of personnel management in the civil service in the context of the development of the information society.
Anastasiia Shulha, Valentyna Serhiienko
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

SOCIAL POLICY IN THE FIELD OF ARCHITECTURAL ACCESSIBILITY FOR PEOPLE WITH LIMITED MOBILITY: INTERNATIONAL EXPERIENCE AND OPPORTUNITIES FOR ADAPTATION IN UKRAINE

Публічне управління та регіональний розвиток
The article analyzes the experience of foreign countries in the field of architectural accessibility for people with limited mobility and the possibilities of its adaptation in Ukraine.
Svitlana Surgova, Olena Faichuk
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Development of a wavelet-based convolutional neural network system for unmanned aerial vehicle type identification via radio frequency fingerprinting

Системи обробки інформації
The growing deployment of unmanned aerial vehicles (UAVs) in both civilian and military domains has created a pressing need for passive, infrastructure-independent identification methods.
I. Sova, O. Kozlov
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

MAIN CHALLENGES ASSOCIATED WITH ENSURING DIGITAL TRANSFORMATION OF COMMUNITIES

Публічне управління та регіональний розвиток
This article examines the digital transformation of communities as a key direction for modernizing public administration and identifies the main challenges arising in the process of ensuring digital transformation of territorial communities (TCs) under ...
Oleksandr Yevtushenko, Oleksii Tsymbalenko   +1 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Kinesio Taping in the Comprehensive Treatment of Post-Stroke Facial Paresis in the Early Recovery Period

Journal of Education, Health and Sport
Background: Ischemic stroke is a leading cause of disability worldwide, with facial paresis being a common neurological complication affecting 45–70% of patients.
D. Khramtsov, N. Morhun
doaj   +1 more source