Results 41 to 50 of about 3,001,593 (308)

Carvacrol: A PL^pro Inhibitor of SARS-CoV-2 Is a Natural Weapon for COVID-19

Chemistry Proceedings, 2022
The outbreak of SARS-CoV-2 created the biggest crisis to human health and has adversely affected economic growth worldwide. Several vaccines emerged from manufacturers to combat COVID-19.
Sudhan Debnath, Bimal Debnath, Pradip Debnath   +2 more
doaj   +1 more source

Seed priming improves endosperm weakening, germination, and subsequent seedling development of Solanum lycocarpum St. Hil.

, 2011
Seed priming is a treatment to improve seed quality and plant growth upon germination and is applied widely to crop species to improve uniformity and yield.
Matos, A. C.B., Toorop, P. E., Matos, A. C. B., Davide, A. C., Faria, J. M. Rocha, Silva, Edvaldo Aparecido Amaral da [UNESP][, Rocha Faria, J. M., Da Silva, E. A.A. [UNESP], Soares, G. C.M., Anese, S., Soares, G. C. M.   +10 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Biopriming in black oat seeds

Científica, 2019
This study performs the microbiolization of black oat seeds with Trichoderma spp. and Bacillus subtilis by physio­logical conditioning, suspension of biological structures, and film coating, improving the control of pathogens and the effect on seed germination and vigor.
Emanuele Junges, Marlove Fátima Brião Muniz, Bruna de Oliveira Bastos, Pâmela Oruoski, Cleudson José Michelon   +4 more
openaire   +2 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Growth of Structure Seeded by Primordial Black Holes [PDF]

The Astrophysical Journal, 2007
10 pages, 5 figures.
Mack, Katherine J., Ostriker, Jeremiah P., Ricotti, Massimo   +2 more
openaire   +2 more sources

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Development and Optimization of Methylcellulose-Based Nanoemulgel Loaded with Nigella sativa Oil for Oral Health Management: Quadratic Model Approach

Molecules, 2022
The present study aimed to develop a local dental nanoemulgel formulation of Nigella sativa oil (NSO) for the treatment of periodontal diseases. NSO purchased from a local market was characterized using a GC–MS technique.
Muhammad H. Sultan, Shamama Javed, Osama Ali Madkhali, Mohammad Intakhab Alam, Yosif Almoshari, Mohammad Ali Bakkari, Durgaramani Sivadasan, Ahmad Salawi, Ameena Jabeen, Waquar Ahsan   +9 more
doaj   +1 more source

Primordial black holes as supermassive black hole seeds

Journal of Cosmology and Astroparticle Physics
Abstract The presence of supermassive black holes (SMBHs, M • ∼ 10 6-10   M ⊙ ) in the first cosmic Gyr ( z ≳ 6 ...
F. Ziparo, S. Gallerani, A. Ferrara
openaire   +2 more sources