Results 1 to 10 of about 13,087 (164)

Inhibition of neuroinflammation by thymoquinone requires activation of Nrf2/ARE signalling [PDF]

International Immunopharmacology, 2017
Thymoquinone is an antioxidant phytochemical that has been shown to inhibit neuroinflammation. However, little is known about the potential roles of intracellular antioxidant signalling pathways in its anti-inflammatory activity.
Ravikanth Velagapudi, Asit Kumar, Bernd L Fiebich   +2 more
exaly   +3 more sources

Response of Skin-Derived and Metastatic Human Malignant Melanoma Cell Lines to Thymoquinone and Thymoquinone-Loaded Liposomes

Pharmaceutics, 2022
Thymoquinone has been proved to be effective against neoplasms, including skin cancer. Its high lipophilicity, however, may limit its potential use as a drug.
Patrycja Kłos, Magdalena Perużyńska, Magdalena Baśkiewicz-Hałasa, Paulina Skupin-Mrugalska, Małgorzata Majcher, Magdalena Sawczuk, Bartosz Szostak, Marek Droździk, Bogusław Machaliński, Dariusz Chlubek   +9 more
doaj   +1 more source

The healing effects of thymoquinone on experimentally induced traumatic tendinopathy in rabbits

Journal of Orthopaedic Surgery and Research, 2023
Objectives Thymoquinone is a major bioactive compound present in the black seeds of the Nigella sativa. Tendon injuries are almost 50% of all musculoskeletal injuries. The recovery of tendon after surgery has become a significant challenge in orthopedics.
Alireza Soltanfar, Abdolhamid Meimandi Parizi, Mohammad Foad-Noorbakhsh, Mansour Sayyari, Aida Iraji   +4 more
doaj   +1 more source

Thymoquinone induces telomere shortening, DNA damage and apoptosis in human glioblastoma cells. [PDF]

PLoS ONE, 2010
A major concern of cancer chemotherapy is the side effects caused by the non-specific targeting of both normal and cancerous cells by therapeutic drugs. Much emphasis has been placed on discovering new compounds that target tumour cells more efficiently ...
Resham Lal Gurung, Shi Ni Lim, Aik Kia Khaw, Jasmine Fen Fen Soon, Kirthan Shenoy, Safiyya Mohamed Ali, Manikandan Jayapal, Swaminathan Sethu, Rajamanickam Baskar, M Prakash Hande   +9 more
doaj   +1 more source

Anti-microsporidial effect of thymoquinone on Encephalitozoon intestinalis infection in vitro

Asian Pacific Journal of Tropical Biomedicine, 2020
Objective: To evaluate the anti-microsporidial effects of the active component of Nigella sativa seeds, thymoquinone, against Encephalitozoon intestinalis using an in vitro model.
Ulfet Cetinkaya, Gülay Sezer, Arzuv Charyyeva   +2 more
doaj   +1 more source

An Evaluation of the Protective Effects of Thymoquinone on Amikacin-Induced Ototoxicity in Rats [PDF]

Clinical and Experimental Otorhinolaryngology, 2015
ObjectivesIn this study we investigated the probable protective effects of thymoquinone on amikacin-induced ototoxicity in rats.MethodsThirty-two healthy rats were divided into four groups (amikacin, amikacin+thymoquinone, thymoquinone, and no treatment).
Fadlullah Aksoy, Remzi Dogan, Orhan Ozturan, Selahattin Tugrul, Bayram Veyseller, Omer Faruk Ozer, Alev Pektas   +6 more
doaj   +1 more source

The Effect of Thymoquinone Administration on Local Immunoglobulin-G Levels of Rattus norvegicus Strain Wistar Sciatic Nerve Crush Injury Model

Indonesian Biomedical Journal, 2022
BACKGROUND: Immunoglobulin-G (IgG) is a product of the initial response to secondary immune response, which accumulates in distal segment of the nerve after crush injury. Thymoquinone modulates the adaptive immune response.
Valentinus Besin, Abdul Hafid Bajamal, Mohammad Hasan Machfoed, Jusak Nugraha, Budi Utomo, Paulus Budiono Notopuro   +5 more
doaj   +1 more source

Thymoquinone Alleviates Cadmium Induced Stress in Germinated Lens culinaris Seeds by Reducing Oxidative Stress and Increasing Antioxidative Activities

Life, 2022
This study investigated the effect of thymoquinone on seeds germination and young seedlings of lentils under cadmium (Cd) stress (300 µM). Three different concentrations (10 µM, 1 µM, and 0.1 µM) of thymoquinone were applied.
Reda Ben Mrid, Abdelhamid Ennoury, Zoulfa Roussi, Imane Naboulsi, Bouchra Benmrid, Anass Kchikich, Redouane El Omari, Mohamed Nhiri, Abdelaziz Yasri   +8 more
doaj   +1 more source

Guesstimate of thymoquinone diversity in Nigella sativa L. genotypes and elite varieties collected from Indian states using HPTLC technique

Open Life Sciences, 2023
Thymoquinone is a valuable metabolite derived from the Nigella sativa L. seeds and has a variety of therapeutic properties. Thymoquinone was estimated using n-hexane:ethyl acetate (8:2, v/v) green solvent system and computed at a wavelength of 254 nm ...
Ravi Y., Vethamoni Irene P., Saxena Shailendra N., Velmurugan S., Santanakrishnan V. P., Raveendran M., Bariya Himanshu, Harsh Mistry   +7 more
doaj   +1 more source

A Method for the Isolation of Thymoquinone from Black Caraway Seed Oil (Nigella sativa L.)

Разработка и регистрация лекарственных средств, 2023
Introduction. Thymoquinone (2-Isopropyl-5-methyl-1,4-benzoquinone) is an organic compound of plant origin, which is formed as a result of the oxidation of thymohydroquinone. Thymoquinone is a component of the essential oil of black caraway seeds (Nigella
A. K. Whaley, Y. V. Burtseva, E. V. Kuldyrkaeva, A. S. Novosad, N. L. Babak, E. V. Zhokhova, A. O. Whaley, M. Yu. Goncharov, I. I. Terninko, G. P. Yakovlev   +9 more
doaj   +1 more source