Results 21 to 30 of about 9,080 (213)

Thymoquinone ameliorates some endocrine parameters and histological alteration in a rat model of polycystic ovary syndrome

International Journal of Reproductive BioMedicine, 2018
Background: Polycystic ovary syndrome (PCOS) is a common form of the endocrine disease which is associated with metabolic dysfunction. PCOS and type 2 diabetes mellitus are related in multiple aspects and are similar in many pathological features.
Sima Taghvaee Javanshir, Parichehreh Yaghmaei, Zahra Hajebrahimi   +2 more
doaj   +1 more source

Is thymoquinone an antioxidant? [PDF]

BMC Pharmacology, 2010
BackgroundThymoquinone is one of the active ingredients of blackcumin (Nigella sativaL.) essential oil possessing anti-inflammatory, antineoplastic, neuro- and hepatoprotec-tive properties. Some of these properties were attributedto an antioxidant activity of thymoquinone, which seemsto be unlikely from its structure. Because the lipophilicthymoquinone
Staniek, Katrin, Gille, Lars
openaire   +1 more source

Integrated In Silico Discovery of Thymoquinone Analogs Targeting the Keap1-Nrf2 Pathway for Amyotrophic Lateral Sclerosis Therapy. [PDF]

ChemistryOpen
Integrated in silico discovery of thymoquinone analogs as potent Keap1 inhibitors for ALS therapy. Using validated QSAR, docking, and 200 ns MD simulations, we identified brain‐penetrant leads (CHEMBL3416163, CHEMBL4636830, and CHEMBL221598) with binding affinities up to fourfold stronger than thymoquinone, offering a targeted strategy to restore redox
Nalicho JC, Mabeyo PE, Paluch AS, Paul L.   +3 more
europepmc   +2 more sources

Thymoquinone improves folliculogenesis, sexual hormones, gene expression of apoptotic markers and antioxidant enzymes in polycystic ovary syndrome rat model

Veterinary Medicine and Science, 2023
Background Nowadays, polycystic ovary syndrome (PCOS) is a prevalent cause of infertility affecting women of reproductive age around the world. Thymoquinone is a natural antioxidant, derived from Nigella sativa.
Sanaz Alaee, Maryam Mirani, Zahra Derakhshan, Farhad Koohpeyma, Azizollah Bakhtari   +4 more
doaj   +1 more source

The effects of thymoquinone on pancreatic cancer and immune cells

, 2022
OBJECTIVES: Black cumin is widely used as a spice and as a traditional treatment. The active ingredient in black cumin seeds is thymoquinone. Thymoquinone has shown anticancer effects in some cancers.
Kancaği, Derya Dilek, Ovali,Ercüment, Yüce,Elif, Özdemir, Feyyaz, Karaku, Gozde Sir s, Karaman,Elanur, Alandağ, Celal, Karakuş Sir,Gözde, Ovali, Ercüment, Özdemir,Feyyaz, Karaman, Elanur, Yüce, Elif, Çakirsoy, Didem, Karakuş, Gözde, Kancaği,Derya Dilek, Alandağ,Celal, Çakirsoy,Didem   +16 more
core   +1 more source

A Method for the Isolation of Thymoquinone from Black Caraway Seed Oil (Nigella sativa L.)

Разработка и регистрация лекарственных средств, 2023
Introduction. Thymoquinone (2-Isopropyl-5-methyl-1,4-benzoquinone) is an organic compound of plant origin, which is formed as a result of the oxidation of thymohydroquinone. Thymoquinone is a component of the essential oil of black caraway seeds (Nigella
A. K. Whaley, Y. V. Burtseva, E. V. Kuldyrkaeva, A. S. Novosad, N. L. Babak, E. V. Zhokhova, A. O. Whaley, M. Yu. Goncharov, I. I. Terninko, G. P. Yakovlev   +9 more
doaj   +1 more source

The Neuroprotective Effects of Thymoquinone: A Review [PDF]

Dose-Response, 2018
Thymoquinone (TQ), one of the main components active of Nigella sativa, exhibited very useful biomedical effects such as anti-inflammatory, antioxidant, antimicrobial, antiparasitic, anticancer, hypoglycemic, antihypertensive, and antiasthmatic effects. There are several studies about pharmacological activities of TQ but its neuroprotection effects are
Tahereh Farkhondeh, Saeed Samarghandian, Ali Mohammad Pourbagher Shahri, Fariborz Samini   +3 more
openaire   +3 more sources

An Overview on Renoprotective Effects of Thymoquinone [PDF]

Kidney Diseases, 2018
<b><i>Background:</i></b> Kidneys as vital organs remove waste material from blood. Additionally, they may also have a role in the electrolyte balance, regulation of blood pressure, and red blood cell genesis. Kidney diseases may be caused by several factors such as ischemia/reperfusion injury, diabetes, and nephrotoxic agents ...
Hanieh, Shaterzadeh-Yazdi, Mohammad-Foad, Noorbakhsh, Saeed, Samarghandian, Tahereh, Farkhondeh   +3 more
openaire   +2 more sources

Thymoquinone, as a Novel Therapeutic Candidate of Cancers [PDF]

Pharmaceuticals, 2021
To date, natural products are widely used as pharmaceutical agents for many human diseases and cancers. One of the most popular natural products that have been studied for anticancer properties is thymoquinone (TQ). As a bioactive compound of Nigella sativa, TQ has shown anticancer activities through the inhibition of cell proliferation, migration, and
Belal Almajali, Hamid Ali Nagi Al-Jamal, Wan Rohani Wan Taib, Imilia Ismail, Muhammad Farid Johan, Abd Almonem Doolaanea, Wisam Nabeel Ibrahim   +6 more
openaire   +4 more sources

Therapeutic perspective of thymoquinone: A mechanistic treatise [PDF]

Food Science & Nutrition, 2021
AbstractThe higher utilization of fruits and vegetables is well known to cure human maladies due to the presence of bioactive components. Among these compounds, thymoquinone, a monoterpene and significant constituent in the essential oil of Nigella sativa L., has attained attention by the researchers due to their pharmacologies perspectives such as ...
Masood Sadiq Butt, Muhammad Imran, Ali Imran, Muhammad Sajid Arshad, Farhan Saeed, Tanweer Aslam Gondal, Mohammad Ali Shariati, Syed Amir Gilani, Tabussam Tufail, Ishtiaque Ahmad, Nadir Ali Rind, Mohamad Fawzi Mahomoodally, Saiful Islam, Zaffar Mehmood   +13 more
openaire   +2 more sources