Results 71 to 80 of about 2,866,338 (297)

Compact radio cores: from the first black holes to the last

open access: yes, 2004
One of the clearest signs of black hole activity is the presence of a compact radio core in the nuclei of galaxies. With the Square Kilometer Array (SKA) these cores can be used to study the evolution of black holes throughout the universe and even to ...
Antonucci   +59 more
core   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Formation of non-steady outflows and QPOs around black hole [PDF]

open access: yes, 2014
We study the time dependent properties of sub-Keplerian viscous accretion flow around the black holes. We find that rotating matter feels centrifugal barrier on the way towards the black holes and eventually, shock transition is triggered allowing a part
Chattopadhyay, Indranil   +2 more
core  

Quasars and their host galaxies

open access: yes, 2006
This review attempts to describe developments in the fields of quasar and quasar host galaxies in the past five. In this time period, the Sloan and 2dF quasar surveys have added several tens of thousands of quasars, with Sloan quasars being found to z>6.
A. Laor   +81 more
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

An Overview of Ancillary Services and HVDC Systems in European Context

open access: yesEnergies, 2019
Liberalization of electricity markets has brought focus on the optimal use of generation and transmission infrastructure. In such a scenario, where the power transmission systems are being operated closer to their critical limits, Ancillary Services (AS)
Abhimanyu Kaushal, Dirk Van Hertem
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Optimization of Power System Black Start partition Target Network Taking into Account the Black Start Space-Time Support Capability of New Energy Station

open access: yesZhongguo dianli
Taking into account the spatiotemporal support capacity of new energy station black start, a target network optimization method for power system black-start zoning is proposed to improve unconventional security defense ability of the new power system ...
Ruixin WANG   +5 more
doaj   +1 more source

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