Results 71 to 80 of about 5,833,269 (278)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Tyler Perry and the Rhetoric of Madea: Contrasting Performances of Perry’s Leading Lady as She Appears on Stage and Screen

Religions, 2019
In this essay, we will explore the variances in Madea’s character and presence on stage and on screen in both productions of Tyler Perry’s Madea Goes to Jail: The Play and Madea Goes to Jail.
Katherine Whitfield, Andre E. Johnson
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Probing Strong Gravitational Fields in X-ray Novae

, 1998
Most X-ray novae (aka soft X-ray transients) contain black hole primaries. In particular, the large mass functions measured for six X-ray novae directly clinch the argument (within general relativity) that they contain black holes.
McClintock, Jeffrey E.
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

The crises in the Middle East: reshaping the region’s geopolitical landscape and altering the global order

Asian Review of Political Economy
The recent events in the Middle East caught most political commentators, observers and thinkers by surprise. Who would have imagined that a non-state actor like Hamas could launch an attack on Israel and create such a complex condition for a powerful ...
Seevan Saeed
doaj   +1 more source

Review of "Misogynoir Transformed: Black Women’s Digital Resistance" by Moya Bailey (New York University Press)

Lateral
Misogynoir Transformed is a pioneering work by Moya Bailey that offers a groundbreaking analysis of misogynoir and the transformative strategies for social change in contemporary digital society.
Yiming Wang
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Review of "Maroon Choreography" by fahima ife (Duke University Press)

Lateral
In Maroon Choreography, fahima ife follows the policing of Black and Indigenous life across Western modernity in a series of meditations on the “discipling” of the English language in literature and pedagogy, asking us to consider how the afterlife or ...
Walter Lucken IV
doaj   +1 more source

Review of "Wayward Lives, Beautiful Experiments: Intimate Histories of Social Upheaval" by Saidiya Hartman (W. W. Norton : Company)

Lateral, 2019
This review considers how Wayward Lives, Beautiful Experiments: Intimate Histories of Social Upheaval poses a challenge to the reader. The invitation is to stay immersed within the everyday lives of Black women and girls, who navigated the terrains of ...
Patrice D Douglass
doaj   +1 more source