Results 61 to 70 of about 3,228,711 (305)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Effect of vermicompost application on the development of plant properties and root architecture analysis with machine learning in Buxus herlandii

Folia Horticulturae
The effects of liquid vermicompost (commercial product) on nutrient content, root architecture, and plant development were studied at doses of 0, 10, 20, 40, and 80 mL · pot−1. Significant increases in plant height (3.5%), shoot length (25%), leaf width (
Sari Ömer, Enginsu Elif, Çelikel Fisun Gürsel   +2 more
doaj   +1 more source

Refining the M_BH-V_c scaling relation with HI rotation curves of water megamaser galaxies [PDF]

, 2013
Black hole - galaxy scaling relations provide information about the coevolution of supermassive black holes and their host galaxies. We compare the black hole mass - circular velocity (MBH - Vc) relation with the black hole mass - bulge stellar velocity ...
Braatz, James A., Greene, Jenny E., Impellizzeri, C. M. Violette, Kuo, Cheng-Yu, Sun, Ai-Lei, Tuttle, Sarah   +5 more
core   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Distribution and Density of Vegetative Hydrilla Propagules in the Sediments of Two New Zealand Lakes [PDF]

, 1999
The distribution and density of hydrilla (Hydrilla verticillata (L.f.)Royle) turions and tubers in two New Zealand lakes were assessed by sampling cores of sediment from Lakes Tutira and Waikapiro each year from 1994 to 1997.
Champion, P.D., Clayton, J.S., Green, J.D., Hofstra, D.E.   +3 more
core  

A Parallax Distance to the Microquasar GRS 1915+105 and a Revised Estimate of its Black Hole Mass

, 2014
Using the Very Long Baseline Array, we have measured a trigonometric parallax for the micro quasar GRS 1915+105, which contains a black hole and a K-giant companion. This yields a direct distance estimate of 8.6 (+2.0,-1.6) kpc and a revised estimate for
Dhawan, V., McClintock, J. E., Narayan, R., Reid, M. J., Remillard, R. A., Steeghs, D., Steiner, J. F.   +6 more
core   +1 more source

Considerate constructors scheme : Glenfarg water treatment works [PDF]

, 2011
The project to modify Glenfarg Water Treatment Works by Scottish Water, working in conjunction with its partners Black and Veatch Ltd. and Scottish Water Solutions, received a gold award and ‘the ultimate accolade’ of ‘The Most Considerate Site 2009’ at ...
Forbes, Doug, Mason, Steve, Murray, Michael   +2 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Safety and Effectiveness of Struvite from Black Water and Urine as a Phosphorus Fertilizer [PDF]

, 2011
To ensure food supply, phosphorus must be recycled, for which an appealing method is using struvite fertilizer from human excreta. One struvite from black water and another from urine were assessed for safety under Dutch regulations, and for ...
Gell, K., Graaff, M., de, Kuntke, P., Ruijter, F.J., de, Smit, A.L.   +4 more
core   +2 more sources