Results 71 to 80 of about 3,228,711 (305)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

AN ALKALI WATER FROM THE BLACK HILLS [PDF]

open access: yesSchool Science and Mathematics, 1912
n ...
openaire   +1 more source

A study on dynamic modeling to examine the impact of reducing water pollution on market condition in the Turkish Black Sea Basin [PDF]

open access: yes
The Black Sea has severe water pollution problems during the last three decades due to tremendous loads of different types of pollutants discharged from the entire basin Therefore, finding solutions to improve the environmental status of the Black Sea is
Higano Yoshiro, Ulger Suleyman
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Interfacial thermal conductance in graphene/black phosphorus heterogeneous structures

open access: yes, 2016
Graphene, as a passivation layer, can be used to protect the black phosphorus from the chemical reaction with surrounding oxygen and water. However, black phosphorus and graphene heterostructures have low efficiency of heat dissipation due to its ...
Cai, Kun   +6 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Ecological studies of the aquatic soil invertebrates in three inundation forests of Central Amazonia

open access: yes, 1975
From January 1971 till August 1972 ecological studies were carried out on the aquatic macroinvertebrates of the benthos community of three Central-Amazonian inundation forests.
Irmler, U.
core  

Our very own coral reef crisis [PDF]

open access: yes, 2002
The past decade has seen trawling operations expand along the edge of the North East Atlantic continental shelf, as stocks of shelf-dwelling species such as cod have declined.
Hall-Spencer, J
core   +1 more source

Extremely Luminous Water Vapor Emission from a Type 2 Quasar at Redshift z = 0.66

open access: yes, 2005
A search for water masers in 47 Sloan Digital Sky Survey Type 2 quasars using the Green Bank Telescope has yielded a detection at a redshift of z = 0.660.
Baudry A.   +3 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

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