Results 101 to 110 of about 93,413 (314)

Am I Still Too Black For You?: Schooling and Secular Change in Skin Tone Effects [PDF]

open access: yes
Analysts disagree about whether the Civil Rights/Black Power eras lessened the influence of skin tone on education. The paper finds that, holding family background constant, the educational disadvantages of dark and very dark blacks persisted between ...
Linda Datcher Loury
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Racial Difference in the Relationship Between Health and Happiness in the United States

open access: yesPsychology Research and Behavior Management, 2020
Sharon Cobb,1 Arash Javanbakht,2 Ebrahim Khalifeh Soltani,3 Mohsen Bazargan,4,5 Shervin Assari4 1School of Nursing, Charles R Drew University of Medicine and Science, Los Angeles, CA, USA; 2Department of Psychiatry and Behavioral Neurosciences, Wayne ...
Cobb S   +4 more
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Racial Discrimination - risk factor for high blood pressure? a survey study

open access: yesOnline Brazilian Journal of Nursing, 2006
The importance of institutional health practices as representative or not of institutional racism in the treatment of the hypertensive client was object of this study.
Isabel CF da Cruz
doaj  

Long-Run Convergence of Ethnic Skill Differentials [PDF]

open access: yes
This paper investigates if the ethnic skill differentials introduced into the United States by the inflow of very dissimilar immigrant groups during the Great Migration of 1880-1910 disappeared during the past century.
George J. Borjas
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Take the money and run: Economic segregation in U.S. metropolitan areas [PDF]

open access: yes
Compared to racial segregation, economic segregation has received little attention in recent empirical literature. Yet a heated debate has arisen concerning Wilson's hypothesis (1987) that increasing economic segregation plays a role in the formation of ...
P. A. Jargowsky
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

The effects of Obama's political success on the self-rated health of Blacks, Hispanics, and Whites [PDF]

open access: yes, 2011
Stress in the social environment can affect individual health. Election of the first Black President of the United States provides an opportunity to assess how a positive change in the macro-political climate impacts the health of Americans.
Timberlake, Jeffrey   +2 more
core  

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