Results 81 to 90 of about 110,841 (306)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Fall 2010 Community Forum Flyer [PDF]
, 2010 This flyer was used to promote the Fall 2010 Community Forum hosted by the UTK Commission for Blacks on October 14 ...
Commission for Blacks,
core
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background American Indians (AIs) have high stroke morbidity and mortality. We compared stroke incidence and mortality in AIs, blacks, and whites. Methods and Results Pooled data from 2 cardiovascular disease cohort studies included 3182 AIs from the SHS
Clemma J. Muller +8 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Spring 2011 Community Forum Flyer [PDF]
, 2011 This flyer was used to promote the Spring 2011 Community Forum hosted by the UTK Commission for Blacks on March 3 ...
Commission for Blacks,
core
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
, 1972 black n. . . it is common to refer to the Protestants as "blacks" and the Roman Catholics as "micks." These phrases may be used in two ways: (1) jokingly, without meaning insult (2) but if it is said seriously it is regarded by both (the ...
core
Increased Metabolic Burden Among Blacks: A Putative Mechanism for Disparate COVID-19 Outcomes
Diabetes, Metabolic Syndrome and Obesity, 2020 Girardin Jean-Louis,1 Arlener D Turner,1 Peng Jin,2 Mengling Liu,2 Carla Boutin-Foster,3 Samy I McFarlane,3 Azizi Seixas1 1Departments of Population Health, Psychiatry, and Biostatistics, New York University Langone Health, New York, NY, USA; 2Department
Jean-Louis G +6 more
doaj