Results 71 to 80 of about 108,735 (304)
Nuclear Physics B, 1986 Abstract We give a new derivation for the properties of radiation appearing to an observer bounded in a space-time domain that has a horizon; this includes the Rindler case (constant accelerating frame) and the Schwarzschild solution (black hole). Because of the global nature of the quantum state, which inevitably extends to space beyond the horizon,
openaire +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Psicologia: Reflexão e Crítica, 2006 The current study aimed at establishing to what extent both internal and external motivations to respond without prejudice towards Blacks would correlate with human values.
Valdiney V. Gouveia +4 more
doaj
The Journal of Thoracic and Cardiovascular Surgery, 2018 Dawn S, Hui, Richard, Lee
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Why do small establishments hire fewer blacks than large ones [PDF]
This paper shows that small establishments are much less likely to hire and employ blacks than are larger establishments. A number of possible explanations for this result are considered, such as differences across establishments in application rates ...
H. J. Holzer
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background American Indians (AIs) have high stroke morbidity and mortality. We compared stroke incidence and mortality in AIs, blacks, and whites. Methods and Results Pooled data from 2 cardiovascular disease cohort studies included 3182 AIs from the SHS
Clemma J. Muller +8 more
doaj +1 more source
Structural changes, employment outcomes, and population adjustments among whites and blacks: 1980-1990 [PDF]
Earnings and employment deteriorated the most for young, less- educated, and/or black males in the 1980s. The most severe deterioration for blacks occurred in the North-Central regions.
Harry J. Holzer, J. Bound
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source