Results 61 to 70 of about 420,972 (312)
Suicide Attempts in Michigan HealthCare System; Racial Differences
Brain Sciences, 2018 Background. Community-based studies have documented racial differences in social, psychiatric, and medical determinants of suicidal ideation; however, less is known about racial differences in the profile of suicide attempts in clinical settings.
Shervin Assari
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Blacks, Cops, and the State of Nature [PDF]
, 2017 This essay offers a new way to conceptualize the “police violence against Blacks” phenomenon. I argue that we should see the situation as an instance of what Thomas Hobbes called the state of nature, that is, a state without effective law.
Donelson, Raff
core +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Brésil(s), 2017 Since 2010, Brazil has been receiving new political migrations, particularly from Haiti, sub-Saharan Africa, Syria and South Asia. This article analyzes how these refugees have resettled in the city of São Paulo. Some have experienced violent expressions
Marie-Caroline Saglio-Yatzimirsky +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Historia y Sociedad, 2012 This article presents a synthesis of different approaches that historians and the authorraised in order to reinterpret the transition period between the old colonial regime and the birth of the republic in the Viceroyalty of New Granada.
Catalina Reyes Cárdenas
doaj
Educational Attainment and Exercise Frequency in American Women; Blacks’ Diminished Returns [PDF]
Women’s Health Bulletin, 2019 Background: Minorities’ diminished returns (MDRs) refer to smaller protects health effects of socioeconomic status (SES) indicators for Blacks and other minority groups than Whites. Objectives: The current study aimed to explore Black - White differences
Shervin Assari
doaj
Critique [of Fascism: A Review of Its History and Its Present Cultural Reality in the Americas] [PDF]
, 1982 Writing from the vantage point of the 1980s, white historians have questioned the earlier simplistic interpretations of Jeffersonian and Jacksonian Democracy.
Cavaioli, Frank J.
core +1 more source