Results 101 to 110 of about 3,363,784 (294)
Advanced Science, EarlyView.In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang +6 more
wiley +1 more source
Proceedings of the first international NMIBC consensus classification meeting
Bladder CancerNon–muscle invasive bladder cancer (NMIBC) is a biologically and clinically heterogeneous disease, accounting for approximately 75% of bladder cancer cases.
Joep J. de Jong +14 more
doaj +1 more source
, 2017 Given the promising control of bladder cancer achieved by combined chemotherapy/radiotherapy with selective transurethral resection, obstacles remain to the treatment of unresectable bladder cancer.
Tsai, Yu-Chieh;Yeh, Chih-Hsien;Tzen, Kai-Yuan;Ho, Pei-Yin;Tuan, Tsung-Fan;Pu, Yeong-Shiau;Cheng, Ann-Lii;Cheng, Jason Chia-Hsien +1 more
core +1 more source
Epidemiology of Bladder Cancer
, 2020 Based on the latest GLOBOCAN data, bladder cancer accounts for 3% of global cancer diagnoses and is especially prevalent in the developed world. In the United States, bladder cancer is the sixth most incident neoplasm.
Saginala, Barsouk, Padala, Aluru, Rawla
core +1 more source
Advanced Science, EarlyView.This study unveiled that METTL14 mediates m6A modification of WDR72 mRNA to stabilize and enhance WDR72 expression, which disrupts TRIM31‐mediated ubiquitination of CBX8 protein and retards its degradation, finally the elevated CBX8 contributes to tumor stemness.
Huijuan Zeng +13 more
wiley +1 more source
Adverse events following intravesical Bacillus Calmette-Guérin therapy in Mater Dei Hospital, Malta [PDF]
, 2016 Introduction: Intravesical administration of Bacillus Calmette-Guerin (BCG), following transurethral resection of bladder tumour, has been shown to reduce recurrence and progression in appropriately selected patients with non-muscle invasive bladder ...
Debattista, Christine +2 more
core
Cell-targeting Nanomedicine for Bladder Cancer: A Cellular Bioengineering Approach for Precise Drug Delivery [PDF]
Bladder cancer poses considerable therapeutic difficulties owing to its elevated rates of recurrence and the constraints of existing treatment methods. This study examines the possibility of cell-targeting nanomedicine as a viable strategy to improve the
Rahdar, Abbas +7 more
core +1 more source
Advanced Science, EarlyView.In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen +8 more
wiley +1 more source
Advanced Science, EarlyView.Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu +15 more
wiley +1 more source