Results 21 to 30 of about 4,818,157 (329)

Circ0008399 Interaction with WTAP Promotes Assembly and Activity of the m6A Methyltransferase Complex and Promotes Cisplatin Resistance in Bladder Cancer

Cancer Research, 2021
A newly characterized circRNA circ0008399 binds WTAP to modulate expression of target RNA through m6A modification and reduce cisplatin sensitivity in bladder cancer, implicating the potential therapeutic value of targeting this axis.
Wenjie Wei, Jiayin Sun, Hui Zhang, Xingyuan Xiao, Chao Huang, Liang Wang, H. Zhong, Yangkai Jiang, Xiaoping Zhang, Guosong Jiang   +9 more
semanticscholar   +1 more source

FTO modifies the m6A level of MALAT and promotes bladder cancer progression

Clinical and Translational Medicine, 2021
Background Nearly a half million people around the world are diagnosed with bladder cancer each year, and an incomplete understanding of its pathogenicity and lack of efficient biomarkers having been discovered lead to poor clinical management of bladder
L. Tao, X. Mu, Haige Chen, D. Jin, Ruiyun Zhang, Yu-yang Zhao, Jie Fan, M. Cao, Zhihua Zhou   +8 more
semanticscholar   +1 more source

Patient-Derived Explants as a Precision Medicine Patient-Proximal Testing Platform Informing Cancer Management

Frontiers in Oncology, 2021
Precision medicine approaches that inform clinical management of individuals with cancer are progressively advancing. Patient-derived explants (PDEs) provide a patient-proximal ex vivo platform that can be used to assess sensitivity to standard of care ...
Abby R. Templeton, Abby R. Templeton, Abby R. Templeton, Abby R. Templeton, Penny L. Jeffery, Penny L. Jeffery, Penny L. Jeffery, Penny L. Jeffery, Patrick B. Thomas, Patrick B. Thomas, Patrick B. Thomas, Patrick B. Thomas, Mahasha P. J. Perera, Mahasha P. J. Perera, Mahasha P. J. Perera, Mahasha P. J. Perera, Mahasha P. J. Perera, Gary Ng, Gary Ng, Alivia R. Calabrese, Alivia R. Calabrese, Alivia R. Calabrese, Alivia R. Calabrese, Clarissa Nicholls, Clarissa Nicholls, Clarissa Nicholls, Nathan J. Mackenzie, Nathan J. Mackenzie, Nathan J. Mackenzie, Nathan J. Mackenzie, Jack Wood, Jack Wood, Jack Wood, Laura J. Bray, Laura J. Bray, Laura J. Bray, Ian Vela, Ian Vela, Ian Vela, Ian Vela, Ian Vela, Erik W. Thompson, Erik W. Thompson, Elizabeth D. Williams, Elizabeth D. Williams, Elizabeth D. Williams, Elizabeth D. Williams   +46 more
doaj   +1 more source

Downregulated exosomal microRNA-148b-3p in cancer associated fibroblasts enhance chemosensitivity of bladder cancer cells by downregulating the Wnt/β-catenin pathway and upregulating PTEN

Cellular Oncology, 2021
Objective Exosomes derived from cancer-associated fibroblasts (CAFs) are known as important drivers of tumor progression. Previously, microRNA (miR)-148b-3p has been found to be upregulated in bladder cancers as well as in body fluids (blood, urine) of ...
Guang Shan, Xike Zhou, J. Gu, Daoping Zhou, Wei Cheng, Huaiguo Wu, Yueping Wang, T. Tang, Xuedong Wang   +8 more
semanticscholar   +1 more source

Clinical commissioning of an adaptive radiotherapy platform: Results and recommendations

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Online adaptive radiotherapy platforms present a unique challenge for commissioning as guidance is lacking and specialized adaptive equipment, such as deformable phantoms, are rare. We designed a novel adaptive commissioning process consisting of end‐to‐end tests using standard clinical resources.
Kelly Kisling, Timothy D. Keiper, Daniela Branco, Grace Gwe‐Ya Kim, Kevin L Moore, Xenia Ray   +5 more
wiley   +1 more source

Bladder Cancer in South Korea: Analysis of Trends and Risk Factors of Bladder Cancer in South Korea Using a Nationwide Database [PDF]

Journal of Urologic Oncology, 2023
Purpose The purpose of this study was to evaluate the incidence rate and trend of bladder cancer in South Korea using a nationwide database. In addition, we aimed to determine the risk factors and their influence on the incidence of bladder cancer ...
Sangjun Yoo, Kyung-Do Han, Kwang Taek Kim, Woo Suk Choi, Yun-Sok Ha, Jeong Hyun Kim, Cheol Kwak   +6 more
doaj   +1 more source

FGFR3 Destabilizes PD-L1 via NEDD4 to Control T-cell–Mediated Bladder Cancer Immune Surveillance

Cancer Research, 2021
NEDD4 links two important molecules associated with targeted therapy and immune surveillance, providing mechanistic rationale and preclinical support for immuno-targeted combination therapy for FGFR3-activated bladder cancer.
Weiqiang Jing, Ganyu Wang, Zhiwei Cui, Gaozhong Xiong, Xin Jiang, Yue Li, Wushan Li, B. Han, Shouzhen Chen, B. Shi   +9 more
semanticscholar   +1 more source

Treatment planning with a 2.5 MV photon beam for radiation therapy

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Purpose The shallow depth of maximum dose and higher dose fall‐off gradient of a 2.5 MV beam along the central axis that is available for imaging on linear accelerators is investigated for treatment of shallow tumors and sparing the organs at risk (OARs) beyond it.
Navid Khaledi, Chris Hayes, Louise Belshaw, Mark Grattan, Rao Khan, James L. Gräfe   +5 more
wiley   +1 more source

Evaluation of patient doses for routine digital radiography procedures toward establishing an institutional diagnostic reference levels: A case study in Sri Lanka

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract The present study was conducted as part of a comprehensive work to establish National Diagnostic Reference Levels (NDRLs) in Sri Lanka for the first time. DRLs can be used as an effective optimization tool for identifying unusually high or low patient doses during X‐ray examinations.
Sachith Welarathna, Sivakumar Velautham, Mihira Wanninayake, Sivananthan Sarasanandarajah   +3 more
wiley   +1 more source

Designing a Pragmatic Intervention to Help Improve the Bladder Cancer Patient Experience

Inquiry: The Journal of Health Care Organization, Provision, and Financing, 2021
Bladder cancer (BC) is the 10 th most common malignancy worldwide and the patient experience is found to be worse than that for patients diagnosed with other cancer types.
Agustina Bessa, Cecilia Bosco, Fidelma Cahill, Beth Russell, Louis Fox, Charlotte Moss, Harriet Wylie, Anna Haire, Saran Green, Deborah Enting, Shamim Khan, Rajesh Nair, Ramesh Thurairaja, Kathryn Chatterton, Suzanne Amery, Nicola Peat, Sue Smith, Stuart Spear, Richard T Bryan, Leila Frodsham, Danny Burke, Jeannie Rigby, Lydia Makaroff, Phil Kelly, Melanie Costin, Christel Häggström, Mieke Van Hemelrijck   +26 more
doaj   +1 more source