Results 41 to 50 of about 3,363,784 (294)

AARS1-Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer. [PDF]

Adv Sci (Weinh)
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Yuan Q, Song T, He Y, Xia S, Huang Y, He W, Yi Q, Wang Z, Wang P, Huang C, Li L, Yin Z, Cheng F, Yu W.   +13 more
europepmc   +2 more sources

CANCER OF THE BLADDER [PDF]

Journal of the American Medical Association, 1912
A year ago I published an account of an early case of carcinoma of the bladder which Dr. Chute and I removed by the transperitoneal route. The so far successful outcome of this case has encouraged me to present a brief summary of this condition in order to bring up several points for discussion in regard to cancer of the bladder; also to endeavor to ...
openaire   +1 more source

Vitamin C and K3 Combination Causes Enhanced Anticancer Activity against RT-4 Bladder Cancer Cells [PDF]

, 2013
Introduction: Vitamin C (VC), Vitamin K3 (VK3) and the combination (VC:VK3) were evaluated against human bladder cancer cell lines RT-4 and T24 to evaluate their synergistic anticancer activity.
Gilloteaux, Jacques, Summers, Jack, Jamison, James, McGuire, Karen   +3 more
core   +1 more source

Measurements of complement factor H-related protein (BTA-TRAK (TM) assay) and nuclear matrix protein (NMP22 assay) - Useful diagnostic tools in the diagnosis of urinary bladder cancer? [PDF]

, 2003
Between 1997 and 2000 we investigated in a prospective study the voided urine samples of all consecutive patients undergoing cystoscopy independent from their clinical background (n=705) with the BTA-TRAK(TM) assay (Bard Diagnostics, Redmont, USA ...
Holdenrieder, Stefan, Stephan Tauber, Karin Hofmann, Reiter, Wolfgang, Brigitte Mahnert, Dorothea Nagel, Hofmann, Karin, Mahnert, Brigitte, Stieber, Petra, Tauber, Stephan, Kriegmair, Martin, Martin Kriegmair, Nikolaus Schmeller, Stefan Holdenrieder, Schmeller, Nikolaus, Wolfgang Reiter, Nagel, Dorothea, Petra Stieber   +17 more
core   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The application of artificial intelligence to microarray data: identification of a novel gene signature to identify bladder cancer progression [PDF]

, 2009
Background: New methods for identifying bladder cancer (BCa) progression are required. Gene expression microarrays can reveal insights into disease biology and identify novel biomarkers.
Wild, P J, Hartmann, A, Wild, PJ, Rehman, I., Stoehr, R, Wild, P.J., Knüchel-Clarke, Ruth, Burger, Maximilian, Rosario, D.J., Hartmann, Arndt, Linkens, D.A., Rehman, I, Abbod, Maysam F., Hamdy, Freddie C., Wild, Peter Johannes, Knuechel, R, Rehman, Ishtiaq, Rosario, Derek J., Knuechel, Ruth, Hartmann, A., Hamdy, F.C., Pilarsky, Christian, Pilarsky, C., Burger, M, Hamdy, FC, Catto, JW, Catto, J W F, Catto, J.W.F., Rosario, DJ, Stöhr, Robert, Wild, Peter J., Linkens, D A, Pilarsky, C, Abbod, M F, Abbod, MF, Hamdy, F C, Burger, M., Rosario, D J, Denzinger, Stefan, Catto, James W.F., Abbod, M.F., Denzinger, S., Hamdy, Freddie, Linkens, Derek A., Stoehr, R., Knuechel, R., Catto, JWF, Catto, James W. F., Denzinger, S, Linkens, DA, Stoehr, Robert   +50 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A cell line derived from BBN (N-butyl-N-[4-hydroxybutyl]-nitrosamine)-induced rat bladder cancer: establishment and scanning electron microscopic cell surface characteristics [PDF]

, 1978
This research was performed to establish a cell line from experimental bladder tumor and to discuss the biological characteristics of the cell line so established. Tissue cultures of epithelial cells were derived from a rat bladder cancer induced by BBN.
Nishi, Mitsuo
core   +1 more source

Bladder-to-bladder metastasis: gallbladder cancer metastasising to the urinary bladder

, 2021
We report a 48-year-old fit and healthy woman who was incidentally diagnosed to have adenocarcinoma of gallbladder after laparoscopic cholecystectomy. Subsequent imaging showed no evidence of regional or distant spread.
J. Abbaraju, S. Mukherjee, G. Russell, S. Madaan   +3 more
core   +1 more source