Results 41 to 50 of about 3,632,283 (294)

A cell line derived from BBN (N-butyl-N-[4-hydroxybutyl]-nitrosamine)-induced rat bladder cancer: establishment and scanning electron microscopic cell surface characteristics [PDF]

, 1978
This research was performed to establish a cell line from experimental bladder tumor and to discuss the biological characteristics of the cell line so established. Tissue cultures of epithelial cells were derived from a rat bladder cancer induced by BBN.
Nishi, Mitsuo
core   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Immune responses to neoadjuvant chemotherapy in muscle invasive bladder cancer [PDF]

, 2018
The secondary effects of chemotherapy, with bone marrow depression and risk of leukopenia, has traditionally been considered being detrimental for the immune system.
Winqvist, Ola, Sherif, Amir,, Sherif, Amir, Amir Sherif, Winerdal, Malin, Malin Winerdal, Ola Winqvist, Sherif, A, Winerdal, M,, Winqvist, O,   +9 more
core   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Inhibition of urothelial carcinoma through targeted type I interferon-mediated immune activation

OncoImmunology, 2019
Type I interferon (IFN-I) has potent anti-tumor effects against urothelial carcinoma (UC) and may be an alternative treatment option for patients who do not respond to Bacillus Calmette-Guerin.
Devin Plote, Woonyoung Choi, Sharada Mokkapati, Debasish Sundi, James E Ferguson, Jon Duplisea, Nigel R. Parker, Seppo Yla-Herttuala, SUO CTC Bladder Committee, David McConkey, Kimberly S. Schluns, Colin P. Dinney   +11 more
doaj   +1 more source

TRAF4 Inhibits Bladder Cancer Progression by Promoting BMP/SMAD Signaling [PDF]

, 2022
Patients with bladder cancer often have a poor prognosis due to the highly invasive and metastatic characteristics of bladder cancer cells. Epithelial-to-mesenchymal transition (EMT) has been causally linked to bladder cancer invasion.
Suriyamurthy, Sudha, Verma, Chandra Shekhar, Dinther, M. van, Marvin, Dieuwke Louise, Xie, F., Lama, Dilraj, Tan, Tuan Zea, van Dinther, Maarten, Lama, D., Suriyamurthy, S., Mei, Hailiang, Verma, C.S., Marvin, D.L., Dijke, P. ten, Iyengar, Prasanna Vasudevan, ten Dijke, Peter, Xie, Feng, Tan, T.Z., Iyengar, P.V., Zhang, Long, Zhang, L., Ritsma, L., Ritsma, Laila, Mei, H.L., van, Dinther M, Lama, D,, Iyengar, PV, Tan, TZ, Dijke, Peter Ten, Marvin, DL, Mei, H, Zhang, L, Suriyamurthy, S, Verma, CS, Xie, F, Sudha Suriyamurthy, Long Zhang, Prasanna Vasudevan Iyengar, Peter ten Dijke, Chandra Shekhar Verma, Laila Ritsma, Tuan Zea Tan, Dieuwke Louise Marvin, Maarten van Dinther, Feng Xie, Hailiang Mei, Dilraj Lama   +46 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Metastatic non-muscle invasive bladder cancer with cervical lymph node metastasis. [PDF]

, 2019
Bladder cancer is a common cancer that may present as superfi cial, invasive, or metastatic disease. Non‐muscle‐invasive bladder cancer (NMIBC) represents the majority of bladder cancer diagnoses, but represents a spectrum of disease with a variable ...
García Martín, Luis, Villar Zarra, Karen, Garrido-Abad, Pablo, Díaz Menéndez, Ariel, Fernández Arjona, Manuel, Garrido Abad, Pablo   +5 more
core   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

AARS1-Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer. [PDF]

Adv Sci (Weinh)
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Yuan Q, Song T, He Y, Xia S, Huang Y, He W, Yi Q, Wang Z, Wang P, Huang C, Li L, Yin Z, Cheng F, Yu W.   +13 more
europepmc   +2 more sources