Results 41 to 50 of about 5,312,533 (302)

Downregulated exosomal microRNA-148b-3p in cancer associated fibroblasts enhance chemosensitivity of bladder cancer cells by downregulating the Wnt/β-catenin pathway and upregulating PTEN

Cellular Oncology, 2021
Objective Exosomes derived from cancer-associated fibroblasts (CAFs) are known as important drivers of tumor progression. Previously, microRNA (miR)-148b-3p has been found to be upregulated in bladder cancers as well as in body fluids (blood, urine) of ...
Guang Shan, Xike Zhou, J. Gu, Daoping Zhou, Wei Cheng, Huaiguo Wu, Yueping Wang, T. Tang, Xuedong Wang   +8 more
semanticscholar   +1 more source

Elevated levels of MMP12 sourced from macrophages are associated with poor prognosis in urothelial bladder cancer

BMC Cancer, 2023
Background Urothelial bladder cancer is most frequently diagnosed at the non-muscle-invasive stage (NMIBC). However, recurrences and interventions for intermediate and high-risk NMIBC patients impact the quality of life.
Iliana K. Kerzeli, Alexandros Kostakis, Polat Türker, Per-Uno Malmström, Tammer Hemdan, Artur Mezheyeuski, Douglas G. Ward, Richard T. Bryan, Ulrika Segersten, Martin Lord, Sara M. Mangsbo   +10 more
doaj   +1 more source

Measurements of complement factor H-related protein (BTA-TRAK (TM) assay) and nuclear matrix protein (NMP22 assay) - Useful diagnostic tools in the diagnosis of urinary bladder cancer? [PDF]

, 2003
Between 1997 and 2000 we investigated in a prospective study the voided urine samples of all consecutive patients undergoing cystoscopy independent from their clinical background (n=705) with the BTA-TRAK(TM) assay (Bard Diagnostics, Redmont, USA ...
Hofmann, Karin, Holdenrieder, Stefan, Kriegmair, Martin, Mahnert, Brigitte, Nagel, Dorothea, Reiter, Wolfgang, Schmeller, Nikolaus, Stieber, Petra, Tauber, Stephan   +8 more
core   +1 more source

Single-Cell Analyses Reveal Mechanisms of Cancer Stem Cell Maintenance and Epithelial–Mesenchymal Transition in Recurrent Bladder Cancer

Clinical Cancer Research, 2021
Purpose: Bladder cancer treatment remains a major clinical challenge due to therapy resistance and a high recurrence rate. Profiling intratumor heterogeneity can reveal the molecular mechanism of bladder cancer recurrence.
Huanjun J Wang, Y. Mei, C. Luo, Qun Huang, Zifeng Wang, Guanming Lu, L. Qin, Zhun Sun, Chaowen Huang, Zhi-Wen Yang, Junxing Chen, Weiguo Yin, C. Qian, Jianming Zeng, Lingwu Chen, Q. Leng, Yan Guo, Guangshuai Jia   +17 more
semanticscholar   +1 more source

The Landscape of Long Non-Coding RNA Dysregulation and Clinical Relevance in Muscle Invasive Bladder Urothelial Carcinoma. [PDF]

, 2019
Bladder cancer is one of the most common cancers in the United States, but few advancements in treatment options have occurred in the past few decades.
Chang, Eric Y, Chu, Megan, High, Rachel A, Li, Wei Tse, Ongkeko, Weg M, Shen, Haotian, Wang-Rodriguez, Jessica, Wong, Lindsay M   +7 more
core   +1 more source

Combined proteome and transcriptome analyses for the discovery of urinary biomarkers for urothelial carcinoma [PDF]

, 2013
Background: Proteomic discovery of cancer biomarkers in body fluids is challenging because of their low abundance in a complex background. Altered gene expression in tumours may not reflect protein levels in body fluids.
A Martin, BM Bolstad, C Parr, C Parr, C Wang, C Yu, D G Ward, D Kaufman, D Tilki, E Cauberg, E Orenes-Piñero, Gordon K Smyth, H Kataoka, H Kawanishi, H Onda, I Waldhauer, J Salo, J Wiśniewski, K Chang, K K Cheng, K Nakamura, L Dyrskjøt, L Mengual, M Babjuk, M Grønborg, M Lindén, M Makridakis, M Muramaki, M P Zeegers, M Sánchez-Carbayo, M Volmer, M Yang, MP Zeegers, N Anderson, N D James, N J Shimwell, N James, N Nagaraj, N Yang, O Nagakawa, P J Johnson, R Bryan, R T Bryan, RA Irizarry, S Ikematsu, S Irmak, S Kageyama, S Ray, S Shariat, T O’Brien, W Wei, Y Chang, Y Chen, Y Lotan, Y Senga   +54 more
core   +6 more sources

Dihydropyrimidinase Like 2 Promotes Bladder Cancer Progression via Pyruvate Kinase M2-Induced Aerobic Glycolysis and Epithelial–Mesenchymal Transition

Frontiers in Cell and Developmental Biology, 2021
BackgroundAerobic glycolysis and epidermal–mesenchymal transition (EMT) play key roles in the development of bladder cancer. This study aimed to investigate the function and the underlying mechanism of dihydropyrimidinase like 2 (DPYSL2) in bladder ...
Jun Zou, Ruiyan Huang, Yanfei Chen, Xiaoping Huang, Huajun Li, Peng Liang, Shan Chen   +6 more
doaj   +1 more source

The prognostic significance of DAPK1 in bladder cancer. [PDF]

PLoS ONE, 2017
Bladder cancer is one of the leading causes of cancer-related death in men, however, there was only limited effective treatment for invasive bladder cancer.
Jian-Yun Xie, Peng-Chen Chen, Jia-Li Zhang, Ze-Shou Gao, Henrique Neves, Shu-Dong Zhang, Qing Wen, Wei-Dong Chen, Hang Fai Kwok, Yao Lin   +9 more
doaj   +1 more source

Anti-tumor effect of AZD8055 against bladder cancer and bladder cancer-associated macrophages

Heliyon, 2023
The increased activity of the mTOR pathway in bladder cancer has been extensively studied, but no satisfactory mTOR inhibitor has been found in bladder cancer.
Weimin Hu, Yunlong Zhang, Jinzhuo Ning, Ming Li, Yuqi Tang, Linzhi Li, Fan Cheng, Weimin Yu   +7 more
doaj   +1 more source

Intrinsic subtypes and bladder cancer metastasis

Asian Journal of Urology, 2016
Recent studies demonstrated that bladder cancers can be grouped into basal and luminal molecular subtypes that possess distinct biological and clinical characteristics.
David J. McConkey, Woonyoung Choi, Andrea Ochoa, Colin P.N. Dinney   +3 more
doaj   +1 more source