Results 71 to 80 of about 844,682 (297)

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Urological Dysfunction

, 2012
Symptoms of urinary dysfunction occur frequently in patients with Parkinson’s disease (PD), particularly men. Irritative symptoms, such as frequency, urgency, and urge incontinence, are reported in 57–83% of patients with PD.
Moore, Henry, Carlos Singer, Singer, Carlos, Henry Moore   +3 more
core   +1 more source

Real-Time MRI of Continent and Stress Incontinent Male Patients after Orthotopic Ileal Neobladder [PDF]

, 2011
Introduction: The aim of this study was to correlate anatomic differences with continence status in male patients after cystoprostatectomy and ileal neobladder using real-time magnetic resonance imaging.
Bauer, Ricarda M., Karin Herrmann, Stief, Christian G., Yasmin Hocaoglu, Ricarda M. Bauer, Hocaoglu, Yasmin, Alexander Karl, Christian G. Stief, Herrmann, Karin, Karl, Alexander   +9 more
core   +1 more source

GDNF‐Enriched Small Extracellular Vesicle‐Loaded ROS‐Scavenging Hydrogel Promotes Neural Regeneration After Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
A glial cell line‐derived neurotrophic factor (GDNF)‐enriched small extracellular vesicle‐loaded reactive oxygen species (ROS)‐scavenging hydrogel integrates sustained neurotrophic delivery with local modulation of oxidative and inflammatory stress after spinal cord injury. The composite hydrogel improves local vesicle retention, protects neural tissue,
Xingyu Zhu, Zhong Liu, Kewei Li, Yuhong Fan, Kangjia Yang, Xiaopeng Sun, Hang Shi, Lixuan Sun, Yang Lou, Min Wang, Peipei Wu, Hui Qian, Qiang Fu, Hua Ding   +13 more
wiley   +1 more source

An Adipocyte MKK3–p38β Axis Preserves Insulin Responsiveness in Mice and Is Reciprocally Altered in Human Obesity

Advanced Science, EarlyView.
The adipocyte MKK3–p38β axis emerges as an adaptive stress‐response pathway during obesity. Human visceral adipose tissue analyses, adipocyte‐specific mouse models, and primary adipocytes show that the MKK3–p38β axis supports insulin responsiveness by restraining p70S6K‐dependent inhibitory IRS1 feedback and preserving AKT–GLUT4 signaling. This pathway
Edgar Bernardo, Nuria Matesanz, Jorge‐Luis Torres, Alba C. Arcones, Juan Ignacio Jiménez‐Loygorri, Alfonso Mora, Leticia Herrera‐Melle, Luis Leiva‐Vega, Maria Elena Rodriguez, Lourdes Hernández‐Cosido, Marta Leon, Paula Yong González, Teresa Durán, Tamara Parracho, Francisca Mulero, Rubén Nogueiras, J. Simon C. Arthur, Angel R. Nebreda, Roger J. Davis, Miguel Marcos, Guadalupe Sabio   +20 more
wiley   +1 more source

Urethral pharmacological mechanisms incontinence and bladder emptying: An updated review

BACKGROUND: The urethral wall consists of layers of striated muscle, circular and longitudinal smooth muscles, collagen fibers, and a vascular plexus. However, the relative contributions of these components to urethral pressure in humans remain poorly ...
Uvelius, Bengt, Andersson, Karl-Erik, Andersson, Karl-Erik,, Uvelius, Bengt,, Lund University.   +4 more
core   +1 more source

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

Relationship between video game addiction and bladder/bowel dysfunction in children

Biomédica: revista del Instituto Nacional de Salud
Introduction. Video games have a strong influence on children and adolescents. Video game addiction has negative effects on children’s health. Objective. To determine the relationship between video game addiction and bladder/bowel dysfunction in children.
Öznur Tiryaki, Dilek Menekşe, Nursan Çınar   +2 more
doaj   +1 more source

Pharmacological treatment of chronic pelvic ischemia

Therapeutic Advances in Urology, 2014
Epidemiological studies have shown that lower urinary tract symptoms, including overactive bladder, commonly occur in both men and women, with an age-related increase in both sexes.
Karl-Erik Andersson, Masanori Nomiya, Norifumi Sawada, Osamu Yamaguchi   +3 more
doaj   +1 more source

Neurosurgical treatment of neurogenic bladder dysfunction

, 2006
Neuromodulation is an appealing technique that can be applied to pediatric neurogenic bladder dysfunction. In this chapter we review pathophysiology, clinics, radiological and neurophysiologycal work-up together with surgical techniques of ...
SIGNORELLI CD, LAVANO A, CHIRCHIGLIA D, SIGNORELLI F, VOLPENTESTA G   +4 more
core